Rituximab Biosimilar, Human IgG2
The rituximab biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant, can be used for ELISA, neutralization, in vitro and in vivo functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by rituximab. The research grade rituximab biosimilar protein, L234A L235A P329G (LALAPG) Fc silent mutant, is for research use only.
Synonyms: B-lymphocyte antigen CD20, MS4A1, B1, Bp35, CVID5, LEU-16, MS4A2, S7, membrane spanning 4-domains A1, FMC7, cluster of differentiate 20
产品参数
| 货号 | C010P.h2 |
|---|---|
| 产品名称 | Rituximab Biosimilar, Human IgG2 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 同种型 | Human IgG1 kappa. |
| 来源 | The Fc silent rituximab was produced in the mammalian cells. |
| 特异性 | The Fc silent rituximab specifically binds to the human TNF alpha. |
| 抗体形式 | 0.2 uM filtered solution, pH 6.5, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The Fc silent rituximab is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | The research grade rituximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Rituximab biosimilar CHO stable cell line is available for licensing to manufacture the rituximab biosimilar protein. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C010P-AAG: Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG1-LALAPG (L234A L235A P329G) Monoclonal Antibody.
Background
B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.
Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.