抗小鼠Ly6G/Ly6C (Gr-1)单克隆抗体(克隆号RB6-8C5)，体内实验级重组，大鼠IgG2b Kappa | Syd Labs PA007627.r2b
体内实验级重组抗小鼠Ly6G/Ly6C（Gr-1）单克隆抗体，大鼠IgG2b Kappa（克隆号：RB6-8C5，货号：PA007627.r2b）是用哺乳动物细胞生产的重组抗体，适用于体外和体内研究，比如体内中性粒细胞耗竭（清除）。Syd Labs PA007627.r2b不变区为大鼠IgG2b kappa (rIgG2b或r2b)，可与重组大鼠IgG2b同型对照抗体配套使用。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。
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| 货号 | PA007627.r2b |
|---|---|
| 产品名称 | 抗小鼠Ly6G/Ly6C (Gr-1)单克隆抗体(克隆号RB6-8C5)，体内实验级重组，大鼠IgG2b Kappa | Syd Labs PA007627.r2b |
| 英文名 | In Vivo Grade Recombinant Anti-mouse Ly6G/Ly6C (Gr-1) Monoclonal Antibody (Clone: RB6-8C5), Rat IgG2b Kappa |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Gr-1, Gr1, Ly-6G, ly-6G.1, ly6C |
| 概述 | Syd Labs 重组抗小鼠Ly6G/Ly6C（Gr-1）单克隆抗体(克隆：RB6-8C5) 是用哺乳动物细胞生产的重组抗体，可与重组大鼠IgG2b同型对照抗体配套使用。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。 |
| 克隆号 | RB6-8C5 |
| 同种型 | 大鼠 IgG2b, kappa |
| 特异性 | 体内实验级重组大鼠单克隆抗体 (克隆：RB6-8C5) 特异性与小鼠 Ly6G/Ly6C (Gr-1) 结合 |
| 应用 | ELISA、中和、功能测定，如生物分析PK和ADA测定，以及用于研究受小鼠Ly6G/Ly6C（Gr-1）蛋白影响的生物途径的测定 |
| 抗体形式 | 0.2 μM过滤溶液，pH 7.4，不含稳定剂或防腐剂 |
| 内毒素 | 根据 LAL 方法，≤1 EU每1mg 蛋白质 |
| 纯度 | >95%（在还原条件下通过SDS-PAGE测定） |
| 运输 | 体内实验级重组抗小鼠Ly6G/Ly6C (Gr-1)单克隆抗体（克隆号RB6-8C5)，大鼠IgG2b Kappa用冰袋运输。收到后，请立即将其存放在下面建议的温度下。 |
| 稳定性与存储 | 使用手动除霜冰箱并避免重复冻融循环。 如果保存在2 至 8°C，自收到之日起可保存1个月。 如果保存在-20 至 -70°C，自收到之日起可保存 12个月。 |
| 注意事项 | PA007627.r2b Syd Labs：抗小鼠Ly6G/Ly6C（Gr-1）单克隆抗体是用哺乳动物细胞生产的，可与重组大鼠IgG2b同型对照抗体配套使用。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。 |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
描述
PA007627.r2b: Syd Labs体内实验级重组抗小鼠Ly6G/Ly6C (Gr-1)单克隆抗体（克隆号RB6-8C5），大鼠IgG2b Kappa（In Vivo Grade Recombinant Anti-mouse Ly6G/Ly6C (Gr-1) Monoclonal Antibody (Clone: RB6-8C5), Rat IgG2b Kappa）
抗小鼠Ly6G抗体（RB6-8C5）部分参考文献:
P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy.
Wang, H., et al. Cell Res. 2015 Jun;25(6):674-90. doi: 10.1038/cr.2015.61. PMID: 25998681
To further confirm the correlation between leukocyte-endothelial adhesion and microglial activation, we depleted leukocytes using an anti-granulocyte receptor-1 (Gr-1) monoclonal antibody (mAb, RB6-8C5). …Treatment with RB6-8C5 significantly suppressed microglial activation. …Flow cytometry analysis of the surface expression of CD11a/CD18, CD11b/CD18 and CD18 on leukocytes (labeled by Ly6G staining) from peripheral blood of Sham mice and CLP (4 h) mice. …For neutrophil depletion, mice were treated with intraperitoneal injection of 250 ?g anti-granulocyte receptor-1 (Gr-1) mAb RB6-8C5 (BioXCell, West Lebanon, NH, USA) or an isotype control (BioXCell) 24 h prior to CLP surgery. …The number of adherent leukocytes (loosely adherent/arrested or firmly adherent) at 4 h post-CLP was increased by 458 ± 102/mm? compared to that in the sham mice (26 ± 10/mm?).
Tags: anti-mouse Ly6G/Ly6C (Gr-1) RB6-8C5; anti-mouse Ly6G/Ly6C (Gr-1) (RB6-8C5) in vivo antibody
Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism.
Waight, J. D., et al. PLoS One. 2011;6(11):e27690. doi: 10.1371/journal.pone.0027690. PMID: 22110722
In mouse models MDSC are broadly defined as CD11b+Gr-1+ cells. …More recently, MDSC have been divided into monocytic and granulocytic subsets, reflecting differential expression of the Ly6C and Ly6G epitopes. …Monocytic MDSC are characterized as CD11b+Ly6C high Ly6G ? or CD11b+Gr-1 low cells whereas granulocytic MDSC are defined as CD11b+Ly6C low Ly6G+ cells or CD11b+Gr-1 high. …Using these additional phenotypic markers, splenocytes from G-CSF-treated mice displayed a prominent expansion of granulocytic-like cells (81.4% granulocytic vs. 8.2% monocytic) compared to control mice (23.5% granulocytic vs. 16.9% monocytic). …Third, to delineate which MDSC subset(s) were affected most, we analyzed these preparations for granulocytic and monocytic fractions based on differential expression of the Ly6C and Ly6G epitopes in the gated CD11b+ fraction.
Tags: anti-mouse Ly6G/Ly6C (Gr-1) RB6-8C5 antibody; anti-mouse Ly6G/Ly6C (Gr-1) antibody (clone RB6-8C5)
了解更多抗小鼠Ly6G/Ly6C (Gr-1)单克隆抗体（clone：RB6-8C5）参考文献，欢迎联系我们（咨询微信：duozhaozhao2024）。
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请记住我们的产品信息: 体内实验级重组抗小鼠Ly6G/Ly6C (Gr-1)单克隆抗体(克隆号RB6-8C5)，大鼠IgG2b Kappa: PA007627.r2b Syd Labs In Vivo Grade Recombinant Anti-mouse Ly6G/Ly6C (Gr-1) Monoclonal Antibody (Clone: RB6-8C5), Rat IgG2b Kappa。