Cetuximab Biosimilar, Human IgA2
Cetuximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant (anti-human EGFR monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by cetuximab.
Synonyms: epidermal growth factor receptor, EGF receptor, ErbB-1, HER1
产品参数
| 货号 | C002P.hA2 |
|---|---|
| 产品名称 | Cetuximab Biosimilar, Human IgA2 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 同种型 | Human IgG1 kappa. |
| 来源 | The anti-human EGFR monoclonal antibody cetuximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in the cetuximab biosimilar CHO stable cell line. |
| 特异性 | The in vivo grade cetuximab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human EGFR. |
| 抗体形式 | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The recombinant monoclonal antibody cetuximab L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | The research grade cetuximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Cetuximab biosimilar CHO stable cell line is available for licensing to manufacture the cetuximab biosimilar protein. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C002P-AAG: Cetuximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Chimeric IgG1 Monoclonal Antibody.
Background
Cetuximab, a chimeric (mouse/human) anti-EGFR monoclonal antibody, is an EGFR inhibitor used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab binds to EGFR and turns off the uncontrolled growth in cancers with EGFR mutations.
Cetuximab can be used for treatment of KRAS wild type colon cancer but has little or no effect in colorectal tumors harboring a KRAS mutation. Before treatment using Erbitux, it is better to do a diagnosis using the real time PCR companion diagnostic test for KRAS, the therascreen KRAS test.