抗人CD4单克隆抗体(克隆号SK3 / Anti-Leu 3a) ，体内实验级重组，小鼠IgG1 Kappa | 悉得（Syd Labs）PA007386.m1
悉得（Syd Labs）体内实验级重组抗人CD4单克隆抗体，小鼠IgG1 Kappa（克隆号SK3 / Anti-Leu 3a，货号：PA007386.m1），纯度>95%，适用于体外和体内研究。其不变区为小鼠Mouse IgG1 Kappa (mIgG1或m1)，可与重组小鼠IgG1同型对照抗体配套使用。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。
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| 货号 | PA007386.m1 |
|---|---|
| 产品名称 | 抗人CD4单克隆抗体(克隆号SK3 / Anti-Leu 3a) ，体内实验级重组，小鼠IgG1 Kappa | 悉得（Syd Labs）PA007386.m1 |
| 英文名 | In Vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a), Mouse IgG1 Kappa |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | 悉得（Syd Labs） |
| 别称 | 分化簇4，leu-3，T4 |
| 概述 | 悉得（Syd Labs）提供重组小鼠IgG1同型对照抗体和重组人IgG1同型对照抗体。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。 |
| 克隆号 | SK3 / Anti-Leu 3a |
| 同种型 | 小鼠 IgG1 kappa |
| 应用 | ELISA，流式细胞术（FC），中和（neutralization），功能测定如生物分析 PK 和 ADA 测定，以及那些用于研究受人CD4蛋白影响的生物学途径的测定。 |
| 免疫源 | 抗人CD4单克隆抗体（克隆：SK3 / Anti-Leu 3a）在哺乳动物细胞中产生 |
| 抗体形式 | 0.2微米过滤溶液，pH 7.4，无稳定剂或防腐剂 |
| 内毒素 | 根据 LAL 方法，≤1 EU每1mg 蛋白质 |
| 纯度 | >95%（在还原条件下通过SDS-PAGE测定） |
| 运输 | 体内实验级重组抗人CD4单克隆抗体，小鼠 IgG1 Kappa(克隆号SK3 / Anti-Leu 3a)用冰袋运输。收到后，请立即将其存放在下面建议的温度下。 |
| 稳定性与存储 | 使用手动除霜冰箱并避免重复冻融循环。 自收到之日起 1 个月，保存在2 至 8°C。 自收到之日起12个月，保存在-20 至 -70°C。 |
| 注意事项 | PA007386.m1 悉得（Syd Labs）提供重组小鼠IgG1同型对照抗体和重组人IgG1同型对照抗体。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。 |
| 产品咨询 | 悉得（Syd Labs）在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系悉得（Syd Labs）中国代理商。 关于悉得（Syd Labs）产品如果有任何技术或其它问题，欢迎随时联系悉得（Syd Labs）国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
描述
了解更多抗人CD4单克隆抗体（clone：SK3）引用文献，请查看：抗人CD4单抗（克隆号SK3）引用文献
抗人CD4抗体（SK3）参考文献:
1. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Andrea Cossarizza,et al.Eur J Immunol. 2019.PMCID: PMC7350392
“These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.”
2. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Andrea Cossarizza,et al.Eur J Immunol. 2021.PMCID: PMC11115438
“The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer-reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state-of-the-art handbook for basic and clinical researchers.”
3. Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
Manuel Albanese,et al.Cell Rep Med. 2024.PMCID: PMC11031382
“Immune cell phenotyping frequently detects lineage-unrelated receptors. Here, we report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer. Filamentous CD32+ nanoprotrusions deposit distinct plasma membrane patches onto target T cells. Transferred receptors confer cell migration and adhesion properties, and macrophage-derived membrane patches render resting CD4 T cells susceptible to infection by serving as hotspots for HIV-1 binding. Antibodies that recognize T cell epitopes enhance CD32-mediated trogocytosis. Such autoreactive anti-HIV-1 envelope antibodies can be found in the blood of HIV-1 patients and, consistently, the percentage of CD32+ CD4 T cells is increased in their blood. This CD32-mediated, antigen-independent cell communication mode transiently expands the receptor repertoire and functionality of immune cells. HIV-1 hijacks this mechanism by triggering the generation of trogocytosis-promoting autoantibodies to gain access to immune cells critical to its persistence.”
悉得（Syd Labs）抗人CD4单克隆抗体(克隆号SK3 / Anti-Leu 3a)，小鼠IgG1 Kappa （货号：PA007386.m1）推荐同型对照抗体:
重组小鼠IgG1同型对照抗体，体内实验级（In Vivo Grade Recombinant Mouse IgG1 Isotype Control Antibody）
悉得（Syd Labs）提供以下体内实验级重组抗人CD4单克隆抗体:
Clenoliximab biosimilar, research grade, anti-human CD4 monoclonal antibody
Ibalizumab biosimilar, research grade, anti-human CD4 monoclonal antibody
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4)
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A)
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2)
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a)
悉得（Syd Labs）提供以下体内实验级重组抗小鼠CD4单克隆抗体:
Recombinant Anti-mouse CD4 monoclonal antibody (Clone: GK1.5)
悉得（Syd Labs）提供以下重组抗人CD4单克隆抗体（流式细胞术用）:
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: OKT4A) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: 13B8.2) for flow cytometry
Recombinant Anti-human CD4 monoclonal antibody (Clone: SK3 / Anti-LEU 3a) for flow cytometry
请记住我们的产品信息: 体内实验级重组抗人CD4单克隆抗体(克隆号SK3 / Anti-Leu 3a)，小鼠IgG1 Kappa: PA007386.m1 悉得（Syd Labs）In Vivo Grade Recombinant Anti-human CD4 Monoclonal Antibody (Clone: SK3 / Anti-Leu 3a), Mouse IgG1 Kappa。