抗小鼠CD28单克隆抗体(克隆号37.51) ，体内实验级重组，小鼠IgG1 kappa | Syd Labs PA007475.m1
体内实验级重组抗小鼠CD28单克隆抗体，小鼠IgG1 kappa(克隆号：37.51，货号：PA007475.m1)是用哺乳动物细胞生产的重组抗体，纯度>95%，适用于体内和体外研究，比如体内 CD28 阻断、体外 T 细胞刺激/激活。Syd Labs PA007475.m1不变区为小鼠Mouse IgG1 Kappa (mIgG1或m1)，可与重组小鼠IgG1同型对照抗体配套使用。样品制备条件和最佳样品稀释度应由研究人员通过实验确定。
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| 货号 | PA007475.m1 |
|---|---|
| 产品名称 | 抗小鼠CD28单克隆抗体(克隆号37.51) ，体内实验级重组，小鼠IgG1 kappa | Syd Labs PA007475.m1 |
| 英文名 | In vivo Grade Recombinant Anti-mouse CD28 Monoclonal Antibody, Mouse IgG1 Kappa (Clone: 37.51) |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | T 细胞特异性表面糖蛋白 CD28，TP44 |
| 概述 | Syd Labs提供重组小鼠IgG1同型对照抗体。样品制备条件和最佳样品稀释应由研究人员通过实验确定。 |
| 克隆号 | 37.51 |
| 同种型 | 小鼠 IgG1 kappa |
| 应用 | ELISA、流式细胞术、中和、功能测定，如生物分析PK和ADA测定，以及用于研究受小鼠CD28蛋白影响的生物途径的测定。 |
| 免疫源 | 体内实验级重组抗小鼠CD28单克隆抗体（克隆：37.51）在哺乳动物细胞中产生 |
| 抗体形式 | 0.2 μM 过滤溶液， pH 7.4，无稳定剂或防腐剂 |
| 内毒素 | 根据 LAL 方法，≤1 EU每1mg 蛋白质 |
| 纯度 | >95%（在还原条件下通过SDS-PAGE测定） |
| 运输 | 体内实验级重组抗小鼠CD28单克隆抗体，小鼠 IgG1 kappa(克隆号37.51) 用冰袋运输。收到后，请立即将其存放在下面建议的温度下。 |
| 稳定性与存储 | 使用手动除霜冰箱并避免重复冻融循环。 自收到之日起 1 个月，保存在2 至 8°C。 自收到之日起12个月，保存在-20 至 -70°C。 |
| 注意事项 | PA007475.m1 Syd Labs提供重组小鼠IgG1同型对照抗体。样品制备条件和最佳样品稀释应由研究人员通过实验确定。 |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
描述
PA007475.m1: Syd Labs体内实验级重组抗小鼠CD28单克隆抗体（克隆号37.51），小鼠IgG1 Kappa（In vivo Grade Recombinant Anti-mouse CD28 Monoclonal Antibody, Mouse IgG1 Kappa (Clone: 37.51)）
抗小鼠CD28单抗（37.51）部分参考文献:
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction
Rouhani, S. J., et al. Nat Commun. 2015 Apr 10;6:6771. doi: 10.1038/ncomms7771. PMID: 25857745
However, Bg2 cells adoptively transferred into MHC-II−/−→Prox1xβ-gal chimeras treated with αCD28 agonistic antibodies also did not proliferate. …CTV-labelled Bg2 cells were adoptively transferred into B6 and MHC-II−/−→Prox1xβ-gal mice treated with PBS, αCD28 or IFN-γ, and proliferation was analysed 3 days later. Plots are gated on Thy1.1+CD4+ cells. Data representative of 2 experiments with 2 mice each. …CD4 co-cultures also received 0.25 μg ml−1 αCD28 (clone 37.51). …Mice were irradiated (6.5 Gy × 2) and reconstituted with a minimum of 2 × 106 bone marrow cells depleted of CD4+ and CD8+ T cells (Miltenyi Biotec) to prevent graft-versus-host disease. …Single colour images of LAMP1 and cathepsin L staining were imported into ImageJ and thresholded to identify positive vesicles as greater than 10 pixels in area.
Tags: anti-mouse CD28 37.51; anti-mouse CD28 37.51 in vivo
Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity
Eberlein, J., et al. J Virol. 2012 Feb;86(4):1955-70. doi: 10.1128/JVI.05949-11. PMID: 22156513
A case in point is the costimulatory triad of CD28, CD80 (B7.1), and CD86 (B7.2), the role of which has been explored in numerous experimental settings. …To date, infections with multiple distinct and related viruses, escalating dosages, and various challenge routes have been employed to ascertain the role of CD28-CD80/86 costimulation preferentially in CD28−/− mice but also complemented by analyses of CD80−/− and/or CD86−/− strains as well as ligand (anti-CD80/86 and CTLA-4Ig) and receptor (anti-CD28 and anti-CTLA-4) blockade. …For the third paradigm, as reviewed previously by Boesteanu and Katsikis (9), the development of the concept that secondary TE responses are less dependent on CD28-CD80/86 costimulation than primary TE responses was based in large part on in vitro experiments. …Although a similar interpretation was proposed for some nonviral model systems (50), this observation is also compatible with the notion of an activating CD80/86 receptor other than CTLA-4 or CD28. …It should be noted that the impaired proliferative expansion of CD28−/− secondary CD8+ TE was also observed in experiments in which wt and CD28−/− CD8+ TM were transferred into separate recipients (not shown), thus ruling out a competitive disadvantage of CD28−/− T cells in the combined AT/rechallenge experiments described above.
Tags: anti-mouse CD28 37.51 in animal model; anti-mouse CD28 37.51 mAb in animal model
Syd Labs抗小鼠CD28单克隆抗体(克隆号37.51)，小鼠IgG1 kappa（货号：PA007475.m1）推荐同型对照抗体:
Syd Labs提供以下体内实验级重组抗小鼠CD28单克隆抗体:
Recombinant Anti-mouse CD28 monoclonal antibody (Clone: PV-1)
Recombinant Anti-mouse CD28 monoclonal antibodies (Clone:37.51)
Syd Labs提供以下体内实验级重组抗人CD28单克隆抗体:
Recombinant Anti-human CD28 monoclonal antibody (Clone: CD28.2)
Recombinant Anti-human CD28 monoclonal antibody (Clone: 15E8)
Recombinant Anti-human CD28 monoclonal antibody (Clone: 9.3)
Recombinant Anti-human CD28 monoclonal antibody (Clone: CD28.3)
Syd Labs提供以下重组抗人CD28单克隆抗体（流式细胞术用）:
Recombinant Anti-human CD28 monoclonal antibody (Clone: CD28.2) for flow cytometry
Recombinant Anti-human CD28 monoclonal antibody (Clone: 15E8) for flow cytometry
Recombinant Anti-human CD28 monoclonal antibody (Clone: 9.3) for flow cytometry
Recombinant Anti-human CD28 monoclonal antibody (Clone: CD28.3) for flow cytometry
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请记住我们的产品信息: 体内实验级重组抗小鼠CD28单克隆抗体(克隆号37.51)，小鼠IgG1 kappa: PA007475.m1 Syd Labs In vivo Grade Recombinant Anti-mouse CD28 Monoclonal Antibody, Mouse IgG1 Kappa (Clone: 37.51)。