Human RNF43 Protein C-His Tag | Syd Labs BP003229
Syd Labs 货号：BP003229 Human RNF43 Protein with the C-His Tag (人 RNF43 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-terminal.It contains Gly24-Tyr197.
产品参数
| 货号 | BP003229 |
|---|---|
| 产品名称 | Human RNF43 Protein C-His Tag | Syd Labs BP003229 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 物种 | Human |
| 来源 | The recombinant Human RNF43 Protein, (amino acids Gly24-Tyr197) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Gly24-Tyr197 |
| 分子量 | The recombinant Human RNF43 protein with the His tag at the C-terminus has a predicted MW of 20.14 kDa. Due to glycosylation, the protein migrates to 28-38 kDa based on Tris-Bis PAGE result. |
| 活性 | The affinity constant of 0.255 uM as determined in SPR assay (Biacore T200). |
| Form | Liquid |
| 形式 | The affinity constant of 0.255 uM as determined in SPR assay (Biacore T200). |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human RNF43 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human RNF43 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human RNF43 Protein performance should be determined experimentally by the investigator. |
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文献
BP003229: Human RNF43 Protein with the C-His Tag (人 RNF43 蛋白 C-His 标签)
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
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