Human AREG Protein N-hFc Tag | Syd Labs BP004916
(悉得）Syd Labs 货号：BP004916 Human AREG Protein with the N-hFc Tag (人 AREG 蛋白 N-hFc 标签) is expressed from HEK293 with hFc tag at the N-Terminus.It contains Ser101-Lys187.
产品参数
| 货号 | AEG-HM201 |
|---|---|
| 产品名称 | Human AREG Protein N-hFc Tag | Syd Labs BP004916 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Amphiregulin; AR; SDGF; AREG; AREGB; CRDGF; MGC13647 |
| 物种 | Human |
| 来源 | The recombinant Human AREG Protein, (amino acids Ser101-Lys187) fused with a hFc tag at the N-terminus, was produced in HEK 293 cells. |
| 产品标签 | N-hFc |
| 生物素化 | no |
| 确定序列 | Ser101-Lys187 |
| 分子量 | The recombinant Human AREG protein with the hFc tag at the N-terminus has a predicted MW of 37.3 kDa. Due to glycosylation, the protein migrates to 45-50 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human AREG protein with the N-hFc tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Biotinylated Anti-AREG Antibody protein with the N-hFc Tag with the EC50 of 27.2ng/ml determined by ELISA. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human AREG Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human AREG Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human AREG Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004916: Human AREG Protein with the N-hFc Tag (人 AREG 蛋白 N-hFc 标签)
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic cancer. AREG may play a critical role in cell migration, invasion, and EMT by activating the EGFR/ERK/NF‑κB signalling pathway in pancreatic cancer cells.
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