Human Noggin Protein No Tag | Syd Labs BP005578

Human Noggin Protein BP005578 Syd Labs

Human Noggin Protein No Tag | Syd Labs BP005578

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(悉得)Syd Labs 货号:BP005578 Human Noggin Protein with No Tag (人 Noggin 蛋白无标签) is expressed from CHO without tag.It contains Gln28-Cys232.

SKU: BP005578 分类: ,

产品参数

货号 BP005578
产品名称Human Noggin Protein No Tag | Syd Labs BP005578
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
别称 Noggin; NOG; SYM1; SYNS1
物种 Human
来源 The recombinant Human Noggin Protein, (amino acids Gln28-Cys232) fused with No Tag, was produced in CHO cells.
Accession Q13253
产品标签 No Tag
生物素化 no
确定序列 Gln28-Cys232
分子量 The recombinant Human Noggin Protein has a predicted MW of 23.05 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.
Form Lyophilized
形式 Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
制剂 It is recommended to reconstitute the lyophilized recombinant Human Noggin Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening.
纯度 >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
内毒素 Less than 1 EU per ug of protein as determined by LAL method.
运输 The recombinant Human Noggin Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
稳定性与储存 '-20 to -80°C for 12 months as supplied from date of receipt.; -20 to -80°C for 3-6 months in unopened state after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
注意事项 Conditions of optimal recombinant Human Noggin Protein performance should be determined experimentally by the investigator.
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文献

BP005578: Human Noggin Protein with No Tag (人 Noggin 蛋白无标签)

 

Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.

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