Human IL-2 R beta&IL-2 R gamma Protein C-hFc Tag | Syd Labs BP004341
(悉得）Syd Labs 货号：BP004341 Human IL-2 R beta&IL-2 R gamma Protein with the C-hFc Tag (人 IL-2 R β&IL-2 R γ 蛋白 C-hFc 标签) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala27-Thr240 (IL-2 R beta)&Leu23-Ala262 (IL-2 R gamma).
产品参数
| 货号 | BP004341 |
|---|---|
| 产品名称 | Human IL-2 R beta&IL-2 R gamma Protein C-hFc Tag | Syd Labs BP004341 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | IL-2RB&IL-2RG; IL-2RG; IL-2R subunit gamma; IL-2R subunit beta; IL-2RB; IL15RB; IL-2 R beta&IL-2 R gamma |
| 物种 | Human |
| 来源 | The recombinant Human IL-2 R beta&IL-2 R gamma Protein, (amino acids Ala27-Thr240(IL-2 R beta) & Leu23-Ala262(IL-2 R gamma)) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | P14784(IL-2 R beta)&P31785-1(IL-2 R gamma) |
| 产品标签 | C-hFc |
| 生物素化 | no |
| 确定序列 | Ala27-Thr240(IL-2 R beta) & Leu23-Ala262(IL-2 R gamma) |
| 分子量 | The recombinant Human IL-2 R beta&IL-2 R gamma protein with the hFc tag at the C-terminus has a predicted MW of 51.3 kDa (IL-2 R beta)&54.6 kDa (IL-2 R gamma). Due to glycosylation, the protein migrates to 65-70 kDa&80-100 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human IL-15RA&IL-15 protein with the C-hFc tag at 2 ug/ml (100 ul/well) on the plate. Dose 21.5 ng/ml determined by ELISA (QC Test). The affinity constant of 0.114 nM as determined in SPR assay (Biacore T200). |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human IL-2 R beta&IL-2 R gamma Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human IL-2 R beta&IL-2 R gamma Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human IL-2 R beta&IL-2 R gamma Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004341: Human IL-2 R beta&IL-2 R gamma Protein with the C-hFc Tag (人 IL-2 R β&IL-2 R γ 蛋白 C-hFc 标签)
Wilms’ tumor 1 (WT1) is a transcription factor which plays a major role in cell proliferation, differentiation, survival, and apoptosis. WT1 was first identified as a tumor suppressor gene in Wilms’ tumor. The expression of survival signaling genes, IL-2, IL-2RB, and IL-2RG, was also suppressed after WT1-siRNA treatment. In addition, the WT1 silencing also inhibited the S phase of the cell cycle and induced cell death.Moreover, transcriptional modulation of IL-2, IL-2RB, and IL2-2RG expression by WT1 was likely involved in this phenotypic change.
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