Human IFN alpha/beta R1 Protein C-His-Avi Tag | Syd Labs BP005558
(悉得）Syd Labs 货号：BP005558 Human IFN alpha/beta R1 Protein with the C-His-Avi Tag (人 IFN α/β R1 蛋白 C-His-Avi 标签) is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Lys28-Lys436.
产品参数
| 货号 | BP005558 |
|---|---|
| 产品名称 | Human IFN alpha/beta R1 Protein C-His-Avi Tag | Syd Labs BP005558 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC |
| 物种 | Human |
| 来源 | The recombinant Human IFN alpha/beta R1 Protein, (amino acids Lys28-Lys436) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | P17181-1 |
| 产品标签 | C-His-Avi |
| 生物素化 | no |
| 确定序列 | Lys28-Lys436 |
| 分子量 | The recombinant Human IFN alpha/beta R1 protein with the His-Avi tag at the C-terminus has a predicted MW of 50.2 kDa. Due to glycosylation, the protein migrates to 74-95 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human IFNAR1 protein with the C-His-Avi tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Anti-IFNAR1 Antibody protein with the C-hFc tag with the EC50 of 0.25 ug/ml determined by ELISA (QC Test). The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human IFN alpha/beta R1 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | It is recommended to reconstitute the lyophilized recombinant Human IFN alpha/beta R1 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human IFN alpha/beta R1 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP005558: Human IFN alpha/beta R1 Protein with the C-His-Avi Tag (人 IFN α/β R1 蛋白 C-His-Avi 标签)
IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.
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