Human GDF15 Protein N-hFc Tag | Syd Labs BP004865
(悉得）Syd Labs 货号：BP004865 Human GDF15 Protein with the N-hFc Tag (人 GDF15 蛋白 N-hFc 标签) is expressed from HEK293 with hFc tag at the N-Terminus.It contains Ala197-Ile308.
产品参数
| 货号 | BP004865 |
|---|---|
| 产品名称 | Human GDF15 Protein N-hFc Tag | Syd Labs BP004865 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta |
| 物种 | Human |
| 来源 | The recombinant Human GDF15 Protein, (amino acids Ala197-Ile308) fused with a hFc tag at the N-terminus, was produced in HEK 293 cells. |
| Accession | Q99988 |
| 产品标签 | N-hFc |
| 生物素化 | no |
| 确定序列 | Ala197-Ile308 |
| 分子量 | The recombinant Human GDF15 protein with the hFc tag at the N-terminus has a predicted MW of 37.9 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human GFRAL protein with the N-hFc tag at 0.5 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Human GDF15 protein with the N-hFc tag with the EC50 of 2.5 ng/ml determined by ELISA. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human GDF15 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | > 95% as determined by Tris-Bis PAGE;> 92% as determined by HPLC |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human GDF15 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human GDF15 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004865: Human GDF15 Protein with the N-hFc Tag (人 GDF15 蛋白 N-hFc 标签)
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
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