Human Claudin 4 Protein-VLP BP003341 Syd Labs
Human Claudin 4 Protein-VLP (CLD-HM104)
Human Claudin 4 Protein-VLP BP003341 Syd Labs
Human Claudin 4 Protein-VLP (CLD-HM104)

Human Claudin 4 Protein-VLP | Syd Labs BP003341

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Human Claudin 4 Protein-VLP BP003341 Syd Labs

Human Claudin 4 Protein-VLP | Syd Labs BP003341

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(悉得）Syd Labs 货号：BP003341 Human Claudin 4 Protein-VLP (人 Claudin 4 蛋白-VLP) is expressed from HEK293.It contains Met1-Val209.

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SKU： BP003341 分类： ,

产品参数

货号 BP003341
产品名称Human Claudin 4 Protein-VLP | Syd Labs BP003341
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
物种 Human
来源 The recombinant Human Claudin 4 Protein-VLP, (amino acids Met1-Val209) , was produced in HEK 293 cells.
生物素化 no
确定序列 Met1-Val209
分子量 The recombinant Human Claudin 4 Protein-VLP has a predicted MW of 23.31 kDa.
活性 Immobilized recombinant Human Claudin 4 VLP at 1 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Anti-Claudin 4 Antibody, hFc tag with the EC50 of 18.4 ng/ml determined by ELISA.
Form Liquid
形式 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
制剂 It is recommended to reconstitute the lyophilized recombinant Human Claudin 4 Protein-VLP in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening.
纯度 >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
内毒素 Less than 1 EU per ug of protein as determined by LAL method.
运输 The recombinant Human Claudin 4 Protein-VLP is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
稳定性与储存 Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
注意事项 Conditions of optimal recombinant Human Claudin 4 Protein-VLP performance should be determined experimentally by the investigator.
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文献

BP003341: Human Claudin 4 Protein-VLP (人 Claudin 4 蛋白-VLP)

 

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

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