Human BACE-1 Protein C-hFc Tag | Syd Labs BP004360
(悉得）Syd Labs 货号：BP004360 Human BACE-1 Protein with the C-hFc Tag (人 BACE-1 蛋白 C-hFc 标签) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr22-Thr457, which will be further processed into Thr22-Thr457(pro-form) & Glu46-Thr457(mature-form).
产品参数
| 货号 | BP004360 |
|---|---|
| 产品名称 | Human BACE-1 Protein C-hFc Tag | Syd Labs BP004360 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Beta-secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46 |
| 物种 | Human |
| 来源 | The recombinant Human BACE-1 Protein, (amino acids Thr22-Thr457) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | NP_036236.1 |
| 产品标签 | C-hFc |
| 生物素化 | no |
| 确定序列 | Thr22-Thr457 |
| 分子量 | The protein has a predicted MW of 75.2 kDa (pro-form) and 72.6 kDa (mature-form). Due to glycosylation, the protein migrates to 85-100 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human BACE-1 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1EU per ug by the LAL method. |
| 运输 | The recombinant Human BACE-1 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human BACE-1 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004360: Human BACE-1 Protein with the C-hFc Tag (人 BACE-1 蛋白 C-hFc 标签)
The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer’s disease (AD). Clinical failures of anti-Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states.
请记住我们的产品信息: 人 BACE-1 蛋白 （C-hFc 标签）BP004360 Syd Labs（Human BACE-1 Protein with the C-hFc Tag）.
