Biotinylated Cynomolgus IL-18BP Protein C-His Tag | Syd Labs BP003553
Syd Labs 货号：BP003553 Biotinylated Cynomolgus IL-18BP Protein with the C-His Tag is expressed from HEK293 with His tag at the C-Terminus.It contains Thr28-Pro207.
产品参数
| 货号 | BP003553 |
|---|---|
| 产品名称 | Biotinylated Cynomolgus IL-18BP Protein C-His Tag | Syd Labs BP003553 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 物种 | Cynomolgus |
| 来源 | The recombinant Biotinylated Cynomolgus IL-18BP Protein, (amino acids Thr28-Pro207) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| 产品标签 | C-His |
| 生物素化 | yes |
| 确定序列 | Thr28-Pro207 |
| 分子量 | The recombinant Biotinylated Cynomolgus IL-18BP protein with the His tag at the C-terminus has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result. |
| 活性 | The affinity constant of 1.67 nM as determined in SPR assay (Biacore T200). |
| Form | Liquid |
| 形式 | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Biotinylated Cynomolgus IL-18BP Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Biotinylated Cynomolgus IL-18BP Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Biotinylated Cynomolgus IL-18BP Protein performance should be determined experimentally by the investigator. |
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文献
BP003553: Biotinylated Cynomolgus IL-18BP Protein with the C-His Tag
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
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