Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg
Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg. The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5).
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| 货号 | C009P.LA.05 |
|---|---|
| 产品名称 | Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | 悉得（Syd Labs） |
| 别称 | Anti-ErbB-2 Humanized Monoclonal Antibody, Anti-c-neu Humanized Monoclonal Antibody |
| 概述 | Recombinant Humanized IgG1 Monoclonal Antibody. |
| 同种型 | Human IgG1 kappa. |
| 来源 | The monoclonal antibody trastuzumab biosimilar was produced in the trastuzumab biosimilar CHO stable cell line, which is available for licensing to manufacture the trastuzumab biosimilar protein. |
| 特异性 | The monoclonal antibody trastuzumab biosimilar specifically binds to the human HER2 / ErbB-2 / c-neu. |
| 应用 | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by trastuzumab. |
| 抗体形式 | 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives. |
| 内毒素 | < 0.05 EU per 1 mg of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5). |
| 线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com或联系我们 |
描述
C009P.LA.05: Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.
There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.
Syd Labs also provides the following anti-ErbB/HER antibody biosimilar proteins:
Panitumumab Biosimilar (HER1, ErbB-1, EGFR)
Cetuximab Biosimilar (HER1, ErbB-1, EGFR)
Pertuzumab Biosimilar (HER2, ErbB-2, c-neu)
Syd Labs also provides the following research grade antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade (VEGF-A)
Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli)
Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Infliximab biosimilar, research grade (TNF alpha)
Adalimumab biosimilar, research grade (TNF alpha)
Rituximab biosimilar, research grade (CD20)
Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF)
Palivizumab Biosimilar, research grade (RSV)
Omalizumab biosimilar, research grade (IgE)
Eculizumab biosimilar, research grade (C5)
Syd Labs provides the following research grade antibody biosimilars used in ADCs:
Tusamitamab biosimilar, research grade, anti-human CEACAM5 monoclonal antibody
Rovalpituzumab biosimilar, research grade, anti-human DLL3 monoclonal antibody
Trastuzumab biosimilar, research grade, anti-human HER2 monoclonal antibody
Cofetuzumab biosimilar, research grade, anti-human PTK7 monoclonal antibody
Ifinatamab biosimilar, research grade, anti-human B7-H3 (CD276) monoclonal antibody
Sacituzumab biosimilar, research grade, anti-human Trop-2 monoclonal antibody
Gemtuzumab biosimilar, research grade, anti-human CD33 monoclonal antibody
Polatuzumab biosimilar, research grade, anti-human CD79B monoclonal antibody
Cetuximab biosimilar, research grade, anti-human EGFR monoclonal antibody
Please remember our product information: Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg: C009P.LA.05 Syd Labs
