Human TYRO3 Protein C-His Tag | Syd Labs BP004742
(悉得）Syd Labs 货号：BP004742 Human TYRO3 Protein with the C-His Tag (人 TYRO3 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Ala41-Trp429.
产品参数
| 货号 | BP004742 |
|---|---|
| 产品名称 | Human TYRO3 Protein C-His Tag | Syd Labs BP004742 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse |
| 物种 | Human |
| 来源 | The recombinant Human TYRO3 Protein, (amino acids Ala41-Trp429) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | Q06418 |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Ala41-Trp429 |
| 分子量 | The recombinant Human TYRO3 protein with the His tag at the C-terminus has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
| 活性 | The affinity constant of 2.36 uM as determined in SPR assay (Biacore T200). |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human TYRO3 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human TYRO3 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human TYRO3 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004742: Human TYRO3 Protein with the C-His Tag (人 TYRO3 蛋白 C-His 标签)
The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the “eat-me” signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
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