Human TRAIL R2/DR5/TNFRSF10B Protein C-hFc Tag | Syd Labs BP004305
(悉得）Syd Labs 货号：BP004305 Human TRAIL R2/DR5/TNFRSF10B Protein with the C-hFc Tag (人 TRAIL R2/DR5/TNFRSF10B 蛋白 C-hFc 标签) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ile56-Glu182.
产品参数
| 货号 | BP004305 |
|---|---|
| 产品名称 | Human TRAIL R2/DR5/TNFRSF10B Protein C-hFc Tag | Syd Labs BP004305 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER |
| 物种 | Human |
| 来源 | The recombinant Human TRAIL R2/DR5/TNFRSF10B Protein, (amino acids Ile56-Glu182) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | O14763-1 |
| 产品标签 | C-hFc |
| 生物素化 | no |
| 确定序列 | Ile56-Glu182 |
| 分子量 | The recombinant Human TRAIL R2/DR5/TNFRSF10B protein with the hFc tag at the C-terminus has a predicted MW of 41.1 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human Trail protein with the C-hFc tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Human TRAIL R2 protein with the C-hFc tag with the EC50 of 4.8 ng/ml determined by ELISA. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in 50mM Tris, 100mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human TRAIL R2/DR5/TNFRSF10B Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1EU per ug by the LAL method. |
| 运输 | The recombinant Human TRAIL R2/DR5/TNFRSF10B Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human TRAIL R2/DR5/TNFRSF10B Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004305: Human TRAIL R2/DR5/TNFRSF10B Protein with the C-hFc Tag (人 TRAIL R2/DR5/TNFRSF10B 蛋白 C-hFc 标签)
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
请记住我们的产品信息: 人 TRAIL R2/DR5/TNFRSF10B 蛋白 （C-hFc 标签）BP004305 Syd Labs（Human TRAIL R2/DR5/TNFRSF10B Protein with the C-hFc Tag）.
