Human PCSK9 Protein BP005358 Syd Labs
Human PCSK9 Protein (PCS-HM190)
Human PCSK9 Protein (PCS-HM190)
Human PCSK9 Protein (PCS-HM190)
Human PCSK9 Protein BP005358 Syd Labs
Human PCSK9 Protein (PCS-HM190)
Human PCSK9 Protein (PCS-HM190)
Human PCSK9 Protein (PCS-HM190)

Human PCSK9 Protein C-His Tag | Syd Labs BP005358

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Human PCSK9 Protein BP005358 Syd Labs

Human PCSK9 Protein C-His Tag | Syd Labs BP005358

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(悉得）Syd Labs 货号：BP005358 Human PCSK9 Protein with the C-His Tag (人 PCSK9 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Gln31-Gln692.

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Syd Labs, Inc.
SKU： BP005358 分类： ,

产品参数

货号 BP005358
产品名称Human PCSK9 Protein C-His Tag | Syd Labs BP005358
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
别称 PC9; PCSK9; FH3; HCHOLA3; LDLCQ1; NARC-1
物种 Human
来源 The recombinant Human PCSK9 Protein, (amino acids Gln31-Gln692) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Accession Q8NBP7-1
产品标签 C-His
生物素化 no
确定序列 Gln31-Gln692
分子量 Due to autocatalytic cleavage, The recombinant Human PCSK9 Protein release the pro-form (59 kDa) and mature form (14 kDa). Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Tris-Bis PAGE result.
活性 Immobilized recombinant Human PCSK9 protein with the C-His tag at 2 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Anti-PCSK9 antibody protein with the C-hFc tag with the EC50 of 0.16 ug/ml determined by ELISA (QC Test). The affinity constant of 0.35 nM as determined in SPR assay (Biacore T200).
Form Liquid
形式 Supplied as 0.22μm filtered solution in 20mM PB, 300mM NaCl, 10% Glycerol (pH 7.4).
制剂 It is recommended to reconstitute the lyophilized recombinant Human PCSK9 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening.
纯度 >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
内毒素 Less than 1 EU per ug of protein as determined by LAL method.
运输 The recombinant Human PCSK9 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
稳定性与储存 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
注意事项 Conditions of optimal recombinant Human PCSK9 Protein performance should be determined experimentally by the investigator.
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文献

BP005358: Human PCSK9 Protein with the C-His Tag (人 PCSK9 蛋白 C-His 标签)

 

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.

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