Human NKp30/NCR3/CD337 Protein C-hFc Tag | Syd Labs BP004324
(悉得）Syd Labs 货号：BP004324 Human NKp30/NCR3/CD337 Protein with the C-hFc Tag (人 NKp30/NCR3/CD337 蛋白 C-hFc 标签) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu19-Thr138.
产品参数
| 货号 | BP004324 |
|---|---|
| 产品名称 | Human NKp30/NCR3/CD337 Protein C-hFc Tag | Syd Labs BP004324 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | CD337; LY117; NCR3; NKp30; 1C7; MALS |
| 物种 | Human |
| 来源 | The recombinant Human NKp30/NCR3/CD337 Protein, (amino acids Leu19-Thr138) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | AAH52582 |
| 产品标签 | C-hFc |
| 生物素化 | no |
| 确定序列 | Leu19-Thr138 |
| 分子量 | The recombinant Human NKp30/NCR3/CD337 protein with the hFc tag at the C-terminus has a predicted MW of 39.8 kDa. Due to glycosylation, the protein migrates to 53-60 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human NKp30 protein with the C-hFc tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Biotinylated Anti-NKp30 Antibody protein with the C-hFc tag with the EC50 of 18.0 ng/ml determined by ELISA (QC Test). The affinity constant of 23.10 nM as determined in SPR assay (Biacore T200). |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human NKp30/NCR3/CD337 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1EU per ug by the LAL method. |
| 运输 | The recombinant Human NKp30/NCR3/CD337 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human NKp30/NCR3/CD337 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004324: Human NKp30/NCR3/CD337 Protein with the C-hFc Tag (人 NKp30/NCR3/CD337 蛋白 C-hFc 标签)
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed “Natural Cytotoxicity Receptors”. These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
请记住我们的产品信息: 人 NKp30/NCR3/CD337 蛋白 （C-hFc 标签）BP004324 Syd Labs（Human NKp30/NCR3/CD337 Protein with the C-hFc Tag）.
