Human LRP-6 Protein BP004345 Syd Labs
Human LRP-6 Protein (LRP-HM306)
Human LRP-6 Protein BP004345 Syd Labs
Human LRP-6 Protein (LRP-HM306)

Human LRP-6 Protein C-mFc Tag | Syd Labs BP004345

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Human LRP-6 Protein BP004345 Syd Labs

Human LRP-6 Protein C-mFc Tag | Syd Labs BP004345

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(悉得）Syd Labs 货号：BP004345 Human LRP-6 Protein with the C-mFc Tag (人 LRP-6 蛋白 C-mFc 标签) is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala20-Pro630.

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Syd Labs, Inc.
SKU： BP004345 分类： ,

产品参数

货号 BP004345
产品名称Human LRP-6 Protein C-mFc Tag | Syd Labs BP004345
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
别称 LRP-6; DCAD2; FLJ90062; FLJ90421
物种 Human
来源 The recombinant Human LRP-6 Protein, (amino acids Ala20-Pro630) fused with a mFc tag at the C-terminus, was produced in HEK 293 cells.
产品标签 C-mFc
生物素化 no
确定序列 Ala20-Pro630
分子量 The recombinant Human LRP-6 protein with the mFc tag at the C-terminus has a predicted MW of 95.3 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Tris-Bis PAGE result.
活性 Immobilized recombinant Biotinylated Human SOST protein with the C-mFc tag at 5 ug/ml (100 ul/well) on the streptavidin precoated plate (5 ug/ml). Dose response curve for the recombinant Human LRP-6 protein with the C-mFc tag with the EC50 of 0.17 ug/ml determined by ELISA.
Form Lyophilized
形式 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
制剂 It is recommended to reconstitute the lyophilized recombinant Human LRP-6 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening.
纯度 >95% by SEC-HPLC and SDS-PAGE under reducing conditions
内毒素 Less than 1 EU per ug of protein as determined by LAL method.
运输 The recombinant Human LRP-6 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
稳定性与储存 '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
注意事项 Conditions of optimal recombinant Human LRP-6 Protein performance should be determined experimentally by the investigator.
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文献

BP004345: Human LRP-6 Protein with the C-mFc Tag (人 LRP-6 蛋白 C-mFc 标签)

 

Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.

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