Human IL-17R alpha/CD217 Protein C-His Tag | Syd Labs BP004314
(悉得）Syd Labs 货号：BP004314 Human IL-17R alpha/CD217 Protein with the C-His Tag (人 IL-17R α/CD217 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Leu33-Trp320.
产品参数
| 货号 | BP004314 |
|---|---|
| 产品名称 | Human IL-17R alpha/CD217 Protein C-His Tag | Syd Labs BP004314 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | CD217; CDw217; IL-17RA; IL17R; CANDF5; IL-7R; IL-7R-alpha; ILRA |
| 物种 | Human |
| 来源 | The recombinant Human IL-17R alpha/CD217 Protein, (amino acids Leu33-Trp320) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Leu33-Trp320 |
| 分子量 | The recombinant Human IL-17R alpha/CD217 protein with the His tag at the C-terminus has a predicted MW of 34.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human IL-17R alpha protein with the C-His tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Human IL-17A protein with the C-His tag with the EC50 of 0.15 ug/ml determined by ELISA (QC Test). The affinity constant of 1.57 nM as determined in SPR assay (Biacore T200). |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human IL-17R alpha/CD217 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human IL-17R alpha/CD217 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human IL-17R alpha/CD217 Protein performance should be determined experimentally by the investigator. |
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文献
BP004314: Human IL-17R alpha/CD217 Protein with the C-His Tag (人 IL-17R α/CD217 蛋白 C-His 标签)
Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22.
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