Human GEP Protein BP004372 Syd Labs
Human GEP Protein (GEP-HM101)
Human GEP Protein BP004372 Syd Labs
Human GEP Protein (GEP-HM101)

Human GEP Protein C-His Tag | Syd Labs BP004372

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Human GEP Protein BP004372 Syd Labs

Human GEP Protein C-His Tag | Syd Labs BP004372

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(悉得）Syd Labs 货号：BP004372 Human GEP Protein with the C-His Tag (人 GEP 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Thr18-Leu593.

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Syd Labs, Inc.
SKU： BP004372 分类： ,

产品参数

货号 BP004372
产品名称Human GEP Protein C-His Tag | Syd Labs BP004372
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
别称 Progranulin; PGRN; Acrogranin; GP88; Glycoprotein 88; PCDGF; PEPI; CLN11; GEP; Granulin; GRN
物种 Human
来源 The recombinant Human GEP Protein, (amino acids Thr18-Leu593) fused with a His tag at the C-terminus, was produced in HEK 293 cells.
Accession P28799-1
产品标签 C-His
生物素化 no
确定序列 Thr18-Leu593
分子量 The recombinant Human GEP protein with the His tag at the C-terminus has a predicted MW of 62.9 kDa. Due to glycosylation, the protein migrates to 75-82 kDa based on Tris-Bis PAGE result.
Form Lyophilized
形式 Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
制剂 It is recommended to reconstitute the lyophilized recombinant Human GEP Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening.
纯度 >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
内毒素 Less than 1EU per ug by the LAL method.
运输 The recombinant Human GEP Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
稳定性与储存 Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution.
注意事项 Conditions of optimal recombinant Human GEP Protein performance should be determined experimentally by the investigator.
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文献

BP004372: Human GEP Protein with the C-His Tag (人 GEP 蛋白 C-His 标签)

 

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset.

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