Human DLL1/Delta1 Protein C-His Tag | Syd Labs BP004410
(悉得）Syd Labs 货号：BP004410 Human DLL1/Delta1 Protein with the C-His Tag (人 DLL1/Delta1 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Gln18-Gly540.
产品参数
| 货号 | BP004410 |
|---|---|
| 产品名称 | Human DLL1/Delta1 Protein C-His Tag | Syd Labs BP004410 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | H-Delta-1; DLL1; DELTA1; DL1 |
| 物种 | Human |
| 来源 | The recombinant Human DLL1/Delta1 Protein, (amino acids Gln18-Gly540) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | NP_005609 |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Gln18-Gly540 |
| 分子量 | The recombinant Human DLL1/Delta1 protein with the His tag at the C-terminus has a predicted MW of 57.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human DLL1/Delta1 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human DLL1/Delta1 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human DLL1/Delta1 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004410: Human DLL1/Delta1 Protein with the C-His Tag (人 DLL1/Delta1 蛋白 C-His 标签)
DLL1, a Notch signaling ligand, is significantly overexpressed in ERα luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERα luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERα patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.
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