Human CTLA-4/CD152 Protein BP005051 Syd Labs
Human CTLA-4/CD152 Protein (CTL-HM241)
Human CTLA-4/CD152 Protein (CTL-HM241)
Human CTLA-4/CD152 Protein (CTL-HM241)
Human CTLA-4/CD152 Protein BP005051 Syd Labs
Human CTLA-4/CD152 Protein (CTL-HM241)
Human CTLA-4/CD152 Protein (CTL-HM241)
CTL-HM241-4

Human CTLA-4/CD152 Protein C-hFc Tag | Syd Labs BP005051

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Human CTLA-4/CD152 Protein BP005051 Syd Labs

Human CTLA-4/CD152 Protein C-hFc Tag | Syd Labs BP005051

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(悉得）Syd Labs 货号：BP005051 Human CTLA-4/CD152 Protein with the C-hFc Tag (人 CTLA-4/CD152 蛋白 C-hFc 标签) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Lys36-Asp161.

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SKU： BP005051 分类： ,

产品参数

货号 BP005051
产品名称Human CTLA-4/CD152 Protein C-hFc Tag | Syd Labs BP005051
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
别称 CTLA4; CD152; ICOS; CELIAC3; GRD4; GSE; ALPS5; IDDM12
物种 Human
来源 The recombinant Human CTLA-4/CD152 Protein, (amino acids Lys36-Asp161) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells.
Accession P16410-1
产品标签 C-hFc
生物素化 no
确定序列 Lys36-Asp161
分子量 The recombinant Human CTLA-4/CD152 protein with the hFc tag at the C-terminus has a predicted MW of 40.1 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Tris-Bis PAGE result.
活性 Immobilized recombinant Human B7-2 protein with the C-hFc tag at 0.5 ug/ml (100 ul/Well) on the plate. Dose response curve for the recombinant Human CTLA-4 protein with the C-hFc tag with the EC50 of 0.12 ug/ml determined by ELISA (QC Test). The affinity constant of 1.1nM as determined in SPR assay (Biacore T200).
Form Lyophilized
形式 Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
制剂 It is recommended to reconstitute the lyophilized recombinant Human CTLA-4/CD152 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening.
纯度 >95% by SEC-HPLC and SDS-PAGE under reducing conditions.
内毒素 Less than 1 EU per ug of protein as determined by LAL method.
运输 The recombinant Human CTLA-4/CD152 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
稳定性与储存 '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
注意事项 Conditions of optimal recombinant Human CTLA-4/CD152 Protein performance should be determined experimentally by the investigator.
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文献

BP005051: Human CTLA-4/CD152 Protein with the C-hFc Tag (人 CTLA-4/CD152 蛋白 C-hFc 标签)

 

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an “off” switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

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