抗小鼠PD-L1 / PD-1双特异性抗体(克隆号10F.9G2.1 / 29F.1A12.1) ，体内实验级重组，小鼠IgG2c- LALAPG Kappa | Syd Labs PA008005.m2cLA
体内实验级重组抗小鼠PD-L1 / PD-1双特异性抗体，小鼠IgG2c-LALAPG Kappa（克隆号：10F.9G2.1 / 29F.1A12.1，货号：PA008005.m2cLA）是用哺乳动物细胞生产的重组抗体，与大鼠抗小鼠 PD L1 抗体 (克隆号：10F.9G2)和大鼠抗小鼠 PD 1 抗体 (克隆号：29F.1A12) 共享可变区序列，可用于免疫组织化学(IHC)，流式细胞术(FC)，以及各种体外和体内功能分析。Syd Labs PA008005.m2cLA可与重组小鼠IgG2c-LALAPG 双特异性同型对照抗体配套使用。
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| 货号 | PA008005.m2cLA |
|---|---|
| 产品名称 | 抗小鼠PD-L1 / PD-1双特异性抗体(克隆号10F.9G2.1 / 29F.1A12.1) ，体内实验级重组，小鼠IgG2c- LALAPG Kappa | Syd Labs PA008005.m2cLA |
| 英文名 | In Vivo Grade Recombinant Anti-mouse PD-L1 / PD-1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10F.9G2.1 / 29F.1A12.1) |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | 程序性细胞死亡蛋白1、程序性死亡配体1、PD 1、CD279、分化簇279、B7-H1、CD274、RMP1-14、10F.9G2 |
| 概述 | 重组抗小鼠 PD L1 / PD 1 双特异性抗体与大鼠抗小鼠 PD-L1 抗体 (克隆号：10F.9G2)和大鼠抗小鼠 PD-1 抗体 (克隆号：29F.1A12) 共享可变区序列。Syd Labs提供重组小鼠IgG2c-LALAPG 双特异性同型对照抗体。 |
| 克隆号 | 10F.9G2.1，与大鼠抗小鼠PD-L1单克隆抗体（克隆号：10F.9G2）的可变区序列相同。29F.1A12.1，与大鼠抗小鼠PD-1单克隆抗体（克隆号：29F.1A12）的可变区序列相同。 |
| 同种型 | 小鼠 IgG2c, kappa |
| 应用 | 免疫组织化学(IHC)，流式细胞术(FC)，以及各种体外和体内功能分析。 |
| 免疫源 | 原始大鼠杂交瘤（克隆名：10F.9G2）是通过用小鼠PD-L1 cDNA和小鼠PD-L1-CHO转染子免疫大鼠而产生的。原始大鼠杂交瘤（克隆名称：29F.1A12）是通过用小鼠PD-1转染的BHK细胞免疫大鼠而产生的。 |
| 抗体形式 | 0.2 μM过滤溶液，1x PBS |
| 内毒素 | 根据 LAL 方法，≤1 EU每1mg 蛋白质 |
| 纯度 | >95%（在还原条件下通过SDS-PAGE测定） |
| 运输 | 体内实验级重组抗小鼠PD-L1 / PD-1双特异性抗体，小鼠IgG2c-LALAPG Kappa（克隆号10F.9G2.1 / 29F.1A12.1）用冰袋运输。收到后，请立即将其存放在下面建议的温度下。 |
| 稳定性与存储 | 使用手动除霜冰箱并避免重复冻融循环。 如果保存在2 至 8°C，自收到之日起可保存3个月。如果保存在-20 至 -70°C，自收到之日起可保存 12个月。 |
| 注意事项 | PA008005.m2cLA Syd Labs：体内实验级重组大鼠抗小鼠PD L1 / PD 1双特异性抗体（小鼠IgG2c-LALAPG kappa）是用哺乳动物细胞生产的重组抗体，可与重组小鼠IgG2c-LALAPG 双特异性同型对照抗体配套使用。 |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
描述
PA008005.m2cLA: 体内实验级重组抗小鼠PD-L1 / PD-1双特异性抗体，小鼠IgG2c-LALAPG Kappa（克隆号10F.9G2.1 / 29F.1A12.1）
背景知识
The rat anti-mouse PD-1 monoclonal antibody 29F.1A12 (rat IgG2a kappa) reacts with the mouse PD-1 protein (programmed death-1 or CD279) encoded by the mouse Pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 29F.1A12 monoclonal antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein.
The rat anti-mouse PD-L1 monoclonal antibody 10F.9G2 (rat IgG2b kappa) reacts with the mouse PD-L1 protein (programmed death ligand-1, B7-H1 or CD274), a member of the B7 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 10F.9G2 monoclonal antibody blocks the binding of the mouse PD-L1 protein to the mouse PD-1 protein.
It is under investigation how the recombinant anti-mouse PD-1 / PD-L1 bispecific antibodies (29F.1A12 / 10F.9G2 and 10F.9G2 / 29F.1A12) behave different from the individual monoclonal antibodies and their combination (29F.1A12 + 10F.9G2).
Our recombinant anti-mouse PD-1 / PD-L1 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: 29F.1A12) and the rat anti-mouse PD-L1 antibody (hybridoma clone name or number: 10F.9G2).
重组抗小鼠 PD-L1 / PD-1 双特异性抗体 (克隆 10F.9G2 / 29F.1A12)相关问答:
Question: How did you design the anti-mouse PD1 / PDL1 bispecific antibody?
Answer: Clone 29F.1A12 is a well-known anti-mouse PD1 antibody available in the market, and Clone 10F.9G2 is the best well-known anti-mouse PDL1 antibody. They are commonly used to block PD-1 signaling in vivo in murine tumor models and other mouse models. These two clones both have extensive multi-year publication records supporting them. In addition, the mouse IgG2c antibody is produced in certain inbred strains such as C57BL/6, C57BL/10, SJL, and NOD, which does not express the mouse IgG2a antibody; the mouse IgG2a antibody is produced in other inbred strains such as BALB/c and Swiss Webster mice, which does not express the mouse IgG2c antibody. Because the C57BL/6 mouse strain is used in most of animal tumor model research, it is better to use the IgG2c antibodies rather than the IgG2a antibodies. The format with the Fc silenced, Fc silent, or Fcs with silenced effector function, such as LALAPG mutation, is the most popular for anti-mouse PD1 antibodies (clones RMP1-14 and 29F.1A12) and anti-mouse PD-L1 antibodies (clone 10F.9G2).
Question: Do you produce any recombinant Fc-silenced 10F.9G2 / 29F.1A12 or 29F.1A12 / 10F.9G2 bispecific antibody?
Answer: Sure, we provide various recombinant Fc silent 10F.9G2 / 29F.1A12 or 29F.1A12 / 10F.9G2 bispecific antibodies, such as mIgG2c LALAPG, mIgG2a LALAPG, and mIgG1 D265A. We also provide custom recombinant antibody production service to produce other engineered versions of recombinant 10F.9G2 / 29F.1A12 and 29F.1A12 / 10F.9G2 bispecific antibodies.
Syd Labs重组抗HEL/HEL双特异性同型对照抗体：
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG1 Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2a Kappa Bispecific Isotype Control Antibody
In vivo Grade Recombinant anti-HEL / HEL Mouse IgG2c Kappa Bispecific Isotype Control Antibody
Syd Labs提供以下抗小鼠PD-L1/PD-1单克隆抗体:
In vivo grade recombinant anti-mouse PD1 monoclonal antibodies (Clone 29F.1A12.1)
In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies (Clone RMP1-14.1)
In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
Syd Labs提供以下抗小鼠PD-L1和PD-1双特异性抗体:
In vivo grade recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (Clone RMP1-14.1 / 29F.1A12.1)
In vivo grade recombinant anti-mouse PD-1 / PD-1 bispecific antibodies (Clone 29F.1A12.1 / RMP1-14.1)
In vivo grade recombinant anti-mouse PD-1 / PD-L1 bispecific antibodies (Clone RMP1-14.1 / 10F.9G2.1)
In vivo grade recombinant anti-mouse PD-L1 / PD-1 bispecific antibodies (Clone 10F.9G2.1 / RMP1-14.1)
In vivo grade recombinant anti-mouse PD-1 / PD-L1 bispecific antibodies (Clone 29F.1A12.1 / 10F.9G2.1)
In vivo grade recombinant anti-mouse PD-L1 / PD-1 bispecific antibodies (Clone 10F.9G2.1 / 29F.1A12.1)
请记住我们的产品信息: Syd Labs（货号：PA008005.m2cLA）体内实验级重组抗小鼠PD-L1 / PD-1双特异性抗体，小鼠IgG2c-LALAPG Kappa（克隆号10F.9G2.1 / 29F.1A12.1）: PA008005.m2cLA Syd Labs In Vivo Grade Recombinant Anti-mouse PD-L1 / PD-1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10F.9G2.1 / 29F.1A12.1)。