Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Trastuzumab biosimilar with the L234A L235A P329G (LALAPG) Fc silent mutation (anti-human HER2 monoclonal antibody, mAb, clone 4D5-8) for in vitro and in vivo assays to study human HER2 biological pathways. The trastuzumab biosimilar with the wild type Fc, the corresponding human IgG1 isotype controls and mutants, and the antibody dilution buffer are also available.
Synonyms: Receptor tyrosine-protein kinase erbB-2, CD340, cluster of differentiation 340, proto-oncogene Neu, Erbb2 (rodent), ERBB2 (human), erythroblastic oncogene B 2, human epidermal growth factor receptor 2.
产品参数
| 货号 | C009P-AAG |
|---|---|
| 产品名称 | Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 克隆号 | 4D5-8. |
| 同种型 | Human IgG1 kappa. |
| 来源 | The anti-human HER2 monoclonal antibody trastuzumab biosimilar with the Fc silent mutation by L234A L235A P329G (LALAPG) was produced in mammalian cells. |
| 特异性 | The trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human HER2 / ErbB-2 / c-neu. |
| 抗体形式 | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | The research grade trastuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Trastuzumab biosimilar (clone huMAb 4D5-8) is the humanized anti-human HER2 mouse monoclonal antibody (clone muMAb 4D5). |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C009P-AAG: Trastuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Trastuzumab, a humanized monoclonal antibody, interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate.
There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1; HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions; when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.