Satumomab Biosimilar, Anti-human TAG-72 Monoclonal Antibody
The cheapest research grade satumomab biosimilar (anti-human TAG-72 monoclonal antibody, mAb) for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by satumomab. The research grade satumomab biosimilarv protein is for research use only.
Synonyms: tumor-associated glycoprotein 72, TAG72
产品参数
| 货号 | C064P |
|---|---|
| 产品名称 | Satumomab Biosimilar, Anti-human TAG-72 Monoclonal Antibody |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 同种型 | Human IgG1 kappa. |
| 来源 | The anti-human TAG-72 monoclonal antibody satumomab biosimilar was produced in mammalian cells. |
| 特异性 | The in vivo grade satumomab biosimilar specifically binds to the human tumor-associated glycoprotein TAG-72. |
| 抗体形式 | 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The research grade satumomab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C064P: Satumomab Biosimilar (Research Grade), Anti-human TAG-72 Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Satumomab Biosimilar uses the same protein sequences as the therapeutic antibody satumomab.
Satumomab is a modified mouse monoclonal antibody which could specifically bind to tumor-associated glycoprotein (TAG-72). Satumomab is usually combined with some radioactive elements to diagnose colorectal cancer and ovarian cancer. Satumomab is also used to study the distribution of tumor cell-associated antigens in breast cancer. The original satumomab monoclonal antibody was produced by purifying the membrane enrichment part of human breast cancer biopsy tissue and immunizing mice. In fact, in addition to colorectal and ovarian cancer, satumomab can also interact with a variety of cancer cells, including gastric cancer, pancreatic cancer, endometrial cancer and lung adenocarcinoma. For a variety of normal adult tissues, except secretory endometrium, B72.3 had no effect or only weak response.
The characteristic that satumomab can bind to tumor antigen TAG-72 has been used in the clinical study of various cancer detection. Serological tests used satumomab showed that 50% of cancer patients could be detected TAG-72 and 4% of the control population could be detected TAG-72. Satumomab is also used to detect embryonic carcinoma and fine needle biopsy in human effusion and as a diagnostic tool to distinguish lung adenocarcinoma from non-small cell lung cancer or malignant mesothelioma. Labeled satumomab-assisted computer scanning is used to study the localization of tumor lesions. The target of satumomab, TAG-72, is a kind of tumor marker with high specificity and few false positive. Because TAG-72 widely exists in all kinds of cancer tissues and has little expression in normal and benign lesions, anti-TAG-72 monoclonal antibody, which uses satumomab as substitute, has been applied to the study of immunohistochemistry and immunocytochemistry. Those monoclonal antibodies have become a useful tool for clinical tumor diagnosis and differential diagnosis.