Phospho-Smad2-S465/S467 + Smad3-S423/S425 Rabbit mAb
HSPC193;HsT17436;JV15-2;LDS1C;LDS3;MADH3
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货号 | AP1343 |
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产品名称 | Phospho-Smad2-S465/S467 + Smad3-S423/S425 Rabbit mAb |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | HSPC193;HsT17436;JV15-2;LDS1C;LDS3;MADH3 |
基因名称 | SMAD2/SMAD3 |
蛋白名 | SMAD2/SMAD3 |
Uniprot/Swissprot ID | Q15796/P84022 |
克隆号 | ARC56314 |
克隆性 | Monoclonal |
来源 | Rabbit |
反应性 | Human, Mouse, Rat |
偶联 | Unconjugated |
注意事项 | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com |
描述
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]