Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Pertuzumab biosimilar with the L234A L235A P329G (LALAPG) Fc silent mutation (anti-human HER2 monoclonal antibody, mAb) for in vitro and in vivo assays to study human HER2 biological pathways. The pertuzumab biosimilar with the wild type Fc, the corresponding human IgG1 isotype controls and mutants, and the antibody dilution buffer are also available.
Synonyms: Receptor tyrosine-protein kinase erbB-2, CD340, cluster of differentiation 340, proto-oncogene Neu, Erbb2 (rodent), ERBB2 (human), erythroblastic oncogene B 2, human epidermal growth factor receptor 2.
产品参数
| 货号 | C006P-AAG |
|---|---|
| 产品名称 | Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 同种型 | Human IgG1 kappa. |
| 来源 | The anti-HER2 monoclonal antibody pertuzumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in mammalian cells. |
| 特异性 | The in vivo grade pertuzumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human HER2/ErbB-2/c-neu. |
| 抗体形式 | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The recombinant monoclonal antibody pertuzumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | Pertuzumab biosimilar CHO stable cell line is available for licensing to manufacture the pertuzumab biosimilar protein. The research grade pertuzumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C006P-AAG: Pertuzumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant humanized IgG1 Monoclonal Antibody.
Background
Pertuzumab, a humanized monoclonal antibody, inhibits HER dimerization and is used for the treatment of HER2-positive metastatic breast cancer, in combination with trastuzumab and docetaxel. By binding to HER2, Pertuzumab inhibits the dimerization of HER2 with other HER receptors, resulting in slowed tumor growth.