Pascolizumab Biosimilar, Anti-human IL-4 Monoclonal Antibody
The cheapest research grade pascolizumab biosimilar (anti-human anti-interleukin-4 (IL-4) monoclonal antibody, mAb) for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by pascolizumab. The research grade pascolizumab biosimilar protein is for research use only.
Synonyms: interleukin 4, IL4, IL-4
产品参数
| 货号 | C059P |
|---|---|
| 产品名称 | Pascolizumab Biosimilar, Anti-human IL-4 Monoclonal Antibody |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 同种型 | Human IgG1 kappa. |
| 来源 | The anti-human Interleukin-4 (IL-4) monoclonal antibody pascolizumab biosimilar was produced in mammalian cells. |
| 特异性 | The in vivo grade pascolizumab biosimilar specifically binds to the human Interleukin-4 (IL-4). |
| 抗体形式 | 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The research grade pascolizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C059P: Pascolizumab Biosimilar (Research Grade), Anti-human IL-4 Monoclonal Antibody
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Pascolizumab Biosimilar uses the same protein sequences as the therapeutic antibody pascolizumab.
Pascolizumab is a humanized monoclonal antibody with therapeutic potential in asthma direct against interleukin-4 (IL-4). In 2002, in vitro studies showed that pascolizumab could effectively neutralize the bioactivity of IL-4, and the binding of pascolizumab to IL-4 had a slow dissociation rate.
Interleukin-4 (IL-4), the target molecular of pascolizumab, is an important cytokine in the early stages of asthma. IL-4 is mainly produced by activated T cells and also comes from a variety of cytokines. IL-4 is a cytokine produced by activated T cells monocytes basophils mast cells and eosinophils. IL-4 binds to IL-4Rα on the surface of effector cells to form dimer between IL-4Rα and γc or IL-13 Rα1, and phosphorylated at the tail of intracellular domain. Then a signal transduction complex is assembled in the intracellular domain of the dimer, and downstream intracellular molecules are activated to promote the transcription of the target gene. The main biological signal transduction pathways involved by IL-4 are JAK-STAT pathway, Ras-ERK pathway and PI3K-PKB pathway. IL-4 has multiple biological functions and therapeutic effects on swelling, hypersensitivity, rheumatoid arthritis, hematopoietic stem cell transplantation, pregnancy, aplastic anemia and ischemic heart disease. In allergic asthma, Th2 cells may resist the immunosuppressive effect of Treg by secreting IL-4, which can interact with IL-4R expressed on the Treg cell, and inhibiting the expression of Foxp3 through STAT6 signaling pathway, affecting the occurrence and development of asthma. Studies have shown that IL-4 mediates important pro-inflammatory effects in asthma, such as induction of IgE-like rearrangement, expression of vascular cell adhesion molecule-1(VCAM-1), promoting eosinophil migration and release of cytokines. Pascolizumab is a monoclonal antibody that neutralizes IL-4, to inhibit asthma-related responses such as activation of T (H)-2 cells and production of immunoglobulin E.