Omalizumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Omalizumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant (anti-human IgE monoclonal antibody) is used for ELISA, neutralization, in vivo functional assays such as bioanalytical PK and ADA assays, and those in vitro and in vivo assays for studying biological pathways affected by omalizumab.
Synonyms: Immunoglobulin E
产品参数
| 货号 | C020P-AAG |
|---|---|
| 产品名称 | Omalizumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 同种型 | Human IgG1. |
| 来源 | The anti-human IgE monoclonal antibody Omalizumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant was produced in mammalian cells. |
| 特异性 | The in vivo grade Omalizumab biosimilar L234A L235A P329G (LALAPG) Fc silent mutant specifically binds to the human immunoglobulin E (IgE) free in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. |
| 抗体形式 | 0.2 uM filtered solution, pH 6.0, no stabilizers or preservatives. |
| 内毒素 | < 0.1 EU per 1 ug of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The recombinant monoclonal antibody Omalizumab L234A L235A P329G (LALAPG) Fc silent mutant is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | Omalizumab biosimilar CHO stable cell line is available for licensing to manufacture the omalizumab protein. The research grade omalizumab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
C020P-AAG: Omalizumab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
Omalizumab is a humanized antibody used to reduce sensitivity to inhaled or ingested allergens, especially in the control of moderate to severe allergic asthma which does not respond to high doses of corticosteroids.
Immunoglobulin E (IgE) found in mammals only exists as monomers consisting of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). In addition to immunity to parasites, IgE plays an essential role in type I hypersensitivity, which manifests various allergic diseases, and allergic conditions, such as anaphylactic reactions to certain drugs, bee stings, and antigen preparations used in specific desensitization immunotherapy.