Mouse Beta Klotho Protein C-His Tag | Syd Labs BP004106
(悉得）Syd Labs 货号：BP004106 Mouse Beta Klotho Protein with the C-His Tag (小鼠 β Klotho 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Phe53-Pro994.
产品参数
| 货号 | BP004106 |
|---|---|
| 产品名称 | Mouse Beta Klotho Protein C-His Tag | Syd Labs BP004106 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 物种 | Mouse |
| 来源 | The recombinant Mouse Beta Klotho Protein, (amino acids Phe53-Pro994) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Phe53-Pro994 |
| 分子量 | The recombinant Mouse Beta Klotho protein with the His tag at the C-terminus has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result. |
| 活性 | The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). |
| Form | Liquid |
| 形式 | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Mouse Beta Klotho Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | > 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Mouse Beta Klotho Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Mouse Beta Klotho Protein performance should be determined experimentally by the investigator. |
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文献
BP004106: Mouse Beta Klotho Protein with the C-His Tag (小鼠 β Klotho 蛋白 C-His 标签)
Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.
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