Mouse ANXA2 Protein N-His Tag | Syd Labs BP004578
(悉得）Syd Labs 货号：BP004578 Mouse ANXA2 Protein with the N-His Tag (小鼠 ANXA2 蛋白 N-His 标签) is expressed from E.coli with His tag at the N-Terminus.It contains Ser2-Asp339.
产品参数
| 货号 | BP004578 |
|---|---|
| 产品名称 | Mouse ANXA2 Protein N-His Tag | Syd Labs BP004578 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Chromobindin-8; Lipocortin II; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; ANXA2; Annexin A2; Annexin II; LIP2PAP-IV; LPC2D; LPC2DP36; p36 |
| 物种 | Mouse |
| 来源 | The recombinant Mouse ANXA2 Protein, (amino acids Ser2-Asp339) fused with a His tag at the N-terminus, was produced in E.coli cells. |
| Accession | P07356 |
| 产品标签 | N-His |
| 生物素化 | no |
| 确定序列 | Ser2-Asp339 |
| 分子量 | The recombinant Mouse ANXA2 protein with the His tag at the N-terminus has a predicted MW of 39.6 kDa same as Tris-Bis PAGE result. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in 20mM MES, 150mM NaCl, 200mM L-arginine, 5mM DTT (pH 5.5). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Mouse ANXA2 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Mouse ANXA2 Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Mouse ANXA2 Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004578: Mouse ANXA2 Protein with the N-His Tag (小鼠 ANXA2 蛋白 N-His 标签)
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
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