Human SEMA4B Protein C-His Tag | Syd Labs BP004458
(悉得)Syd Labs 货号:BP004458 Human SEMA4B Protein with the C-His Tag (人 SEMA4B 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Leu44-Glu717.
产品参数
| 货号 | BP004458 |
|---|---|
| 产品名称 | Human SEMA4B Protein C-His Tag | Syd Labs BP004458 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Semaphorin-4B; Semaphorin-C; SEMA4B; KIAA1745; SEMAC; MGC131831; SemC |
| 物种 | Human |
| 来源 | The recombinant Human SEMA4B Protein, (amino acids Leu44-Glu717) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | Q9NPR2 |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Leu44-Glu717 |
| 分子量 | The recombinant Human SEMA4B protein with the His tag at the C-terminus has a predicted MW of 75.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human SEMA4B Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human SEMA4B Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human SEMA4B Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品,不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题,欢迎随时联系Syd Labs国内市场推广合作伙伴:武汉多找找科技有限公司,企业微信:duozhaozhao2024 联系电话:18162581039(龙经理) |
文献
BP004458: Human SEMA4B Protein with the C-His Tag (人 SEMA4B 蛋白 C-His 标签)
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
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