Human Kremen-1 Protein C-hFc Tag | Syd Labs BP004813
(悉得）Syd Labs 货号：BP004813 Human Kremen-1 Protein with the C-hFc Tag (人 Kremen-1 蛋白 C-hFc 标签) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Arg21-Thr392.
产品参数
| 货号 | BP004813 |
|---|---|
| 产品名称 | Human Kremen-1 Protein C-hFc Tag | Syd Labs BP004813 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Kremen protein 1; KREMEN; KRM1; KREMEN1 |
| 物种 | Human |
| 来源 | The recombinant Human Kremen-1 Protein, (amino acids Arg21-Thr392) fused with a hFc tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | Q96MU8-1 |
| 产品标签 | C-hFc |
| 生物素化 | no |
| 确定序列 | Arg21-Thr392 |
| 分子量 | The recombinant Human Kremen-1 protein with the hFc tag at the C-terminus has a predicted MW of 67.6 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human Kremen-1 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | It is recommended to reconstitute the lyophilized recombinant Human Kremen-1 Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 week, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution. |
| 注意事项 | Conditions of optimal recombinant Human Kremen-1 Protein performance should be determined experimentally by the investigator. |
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文献
BP004813: Human Kremen-1 Protein with the C-hFc Tag (人 Kremen-1 蛋白 C-hFc 标签)
KREMEN1 (KRM1) has been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD), which poses a great threat to infants globally. KRM1 selectively binds to the mature viral particle above the canyon of the viral protein 1 (VP1) subunit and contacts across two adjacent asymmetry units. The key residues for receptor binding are conserved among most KRM1-dependent enteroviruses, suggesting a uniform mechanism for receptor binding.
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