Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein C-His-Avi Tag | Syd Labs BP005189
(悉得）Syd Labs 货号：BP005189 Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein with the C-His-Avi Tag (人整合素 alpha V beta 8 （ITGAV&ITGB8） 异二聚体蛋白 C-His-Avi 标签) is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail.
产品参数
| 货号 | BP005189 |
|---|---|
| 产品名称 | Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein C-His-Avi Tag | Syd Labs BP005189 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | Integrin alpha V beta 8; TGAV&ITGB8 |
| 物种 | Human |
| 来源 | The recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, (amino acids Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | P06756-1(ITGAV)&P26012-1(ITGB8) |
| 产品标签 | C-His-Avi |
| 生物素化 | no |
| 确定序列 | Phe31-Val992(ITGAV) acidic tail & Glu43-Arg684(ITGB8) basic tail |
| 分子量 | The recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer protein with the His-Avi tag at the C-terminus has a predicted MW of 114 kDa (ITGAV) and 76 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-150 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human ITGAV&ITGB8 protein with the C-His-Avi tag at 5 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Biotinylated Human Latent TGF beta 1 protein with the C-His tag with the EC50 of 0.85 ug/ml determined by ELISA. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Biotinylated Human TPBG/5T4 Protein performance should be determined experimentally by the investigator. |
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文献
BP005189: Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein with the C-His-Avi Tag (人整合素 alpha V beta 8 （ITGAV&ITGB8） 异二聚体蛋白 C-His-Avi 标签)
Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation.
请记住我们的产品信息: 人整合素 alpha V beta 8 （ITGAV&ITGB8） 异二聚体蛋白 （C-His-Avi 标签）BP005189 Syd Labs（Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein with the C-His-Avi Tag）.