Human IL-17RB Protein C-His Tag | Syd Labs BP004750
(悉得）Syd Labs 货号：BP004750 Human IL-17RB Protein with the C-His Tag (人 IL-17RB 蛋白 C-His 标签) is expressed from HEK293 with His tag at the C-Terminus.It contains Arg18-Per292.
产品参数
| 货号 | BP004750 |
|---|---|
| 产品名称 | Human IL-17RB Protein C-His Tag | Syd Labs BP004750 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | IL-17 receptor B; IL-17RB; IL-17ER; Evi27; IL-17 RH1; IL-17ER; IL17RB |
| 物种 | Human |
| 来源 | The recombinant Human IL-17RB Protein, (amino acids Arg18-Per292) fused with a His tag at the C-terminus, was produced in HEK 293 cells. |
| 产品标签 | C-His |
| 生物素化 | no |
| 确定序列 | Arg18-Per292 |
| 分子量 | The recombinant Human IL-17RB protein with the His tag at the C-terminus has a predicted MW of 31.4 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human IL-17RB protein with the C-His tag at 0.2 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Anti-IL-17RB Antibody protein with the C-hFc tag with the EC50 of 5.4 ng/ml determined by ELISA (QC Test). The affinity constant of 0.81 nM as determined in SPR assay (Biacore T200). |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human IL-17RB Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human IL-17RB Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human IL-17RB Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP004750: Human IL-17RB Protein with the C-His Tag (人 IL-17RB 蛋白 C-His 标签)
Among inflammatory mediators, a growing body of evidence emphasizes the contribution of the interleukin 17 (IL-17) cytokine family in malignant diseases. Besides IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. In mouse models, IL-17B signaling through IL-17RB directly promotes cancer cell survival, proliferation, and migration, and induces resistance to conventional chemotherapeutic agents.
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