Human FGFR3 beta (IIIb) Protein C-His-Avi Tag | Syd Labs BP005702
(悉得）Syd Labs 货号：BP005702 Human FGFR3 beta (IIIb) Protein with the C-His-Avi Tag (人 FGFR3 β （IIIb） 蛋白 C-His-Avi 标签) is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Asp127-Gly377.
产品参数
| 货号 | BP005702 |
|---|---|
| 产品名称 | Human FGFR3 beta (IIIb) Protein C-His-Avi Tag | Syd Labs BP005702 |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4 |
| 物种 | Human |
| 来源 | The recombinant Human FGFR3 beta (IIIb) Protein, (amino acids Asp127-Gly377) fused with a His-Avi tag at the C-terminus, was produced in HEK 293 cells. |
| Accession | P22607-2 |
| 产品标签 | C-His-Avi |
| 生物素化 | no |
| 确定序列 | Asp127-Gly377 |
| 分子量 | The recombinant Human FGFR3 beta (IIIb) protein with the His-Avi tag at the C-terminus has a predicted MW of 30.5 kDa. Due to glycosylation, the protein migrates to 40-55 kDa based on Tris-Bis PAGE result. |
| 活性 | Immobilized recombinant Human FGFR3 beta (IIIb) protein with the C-His-Avi tag at 1 ug/ml (100 ul/well) on the plate. Dose response curve for the recombinant Anti-FGFR3 Antibody protein with the C-hFc tag with the EC50 of 10.9 ng/ml determined by ELISA. |
| Form | Lyophilized |
| 形式 | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 制剂 | It is recommended to reconstitute the lyophilized recombinant Human FGFR3 beta (IIIb) Protein in sterile H2O to a protein concentration not less than 100 ug/ml. Centrifuge the tube before opening. |
| 纯度 | >95% by SEC-HPLC and SDS-PAGE under reducing conditions. |
| 内毒素 | Less than 1 EU per ug of protein as determined by LAL method. |
| 运输 | The recombinant Human FGFR3 beta (IIIb) Protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与储存 | '-20 to -80°C for 12 months as supplied from date of receipt.； -20 to -80°C for 3-6 months in unopened state after reconstitution.； 2-8°C for 2-7 days after reconstitution.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| 注意事项 | Conditions of optimal recombinant Human FGFR3 beta (IIIb) Protein performance should be determined experimentally by the investigator. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
BP005702: Human FGFR3 beta (IIIb) Protein with the C-His-Avi Tag (人 FGFR3 β （IIIb） 蛋白 C-His-Avi 标签)
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
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