HER2/ErbB2 Rabbit mAb (A21248)
(悉得）Syd Labs HER2/ErbB2 Rabbit mAb (Catalog Number: A21248) encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors.
产品参数
| 货号 | A21248 |
|---|---|
| 产品名称 | HER2/ErbB2 Rabbit mAb (A21248) |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | Syd Labs |
| 别称 | NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2) |
| 基因名称 | ERBB2 |
| 蛋白名 | ERBB2 |
| Uniprot/Swissprot ID | P04626 |
| Entrez GeneID | 2064 |
| 克隆号 | ARC5120-02 |
| 克隆性 | Monoclonal |
| 来源 | Rabbit |
| 反应性 | Human |
| 偶联 | Unconjugated |
| 注意事项 | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
| 产品咨询 | Syd Labs在国内只通过代理商销售其产品，不做直销。终端用户咨询价格请联系Syd Labs中国代理商。 关于Syd Labs产品如果有任何技术或其它问题，欢迎随时联系Syd Labs国内市场推广合作伙伴：武汉多找找科技有限公司，企业微信：duozhaozhao2024 联系电话：18162581039（龙经理） |
文献
A21248: HER2/ErbB2 Rabbit mAb
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Immunogen Information about HER2/ErbB2 Rabbit mAb (A21248)
Immunogen：Recombinant protein of human HER2/ErbB2.
Sequence：service@abclonal.com
Gene ID：2064
Swiss prot：P04626
Synonyms：NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2); HER2/ErbB2
Calculated MW：138kDa
Observed MW：185kDa
Please remember our product information: HER2/ErbB2 Rabbit mAb (Catalog Number: A21248) (悉得）Syd Labs
