GSK923295
Synonyms: GSK-923295. GSK 923295
GSK923295 (GSK-923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity (Ki = 3.2 nM) [1]. GSK923295 displays a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors. It it currently in clinical evaluations.
产品参数
| 货号 | APIM050303 |
|---|---|
| 产品名称 | GSK923295 |
文献
APIM050303: GSK923295 (GSK-923295)
CAS No.: 1088965-37-0
IUPAC/Chemical Name: 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide
Molecular Formula: C32H38ClN5O4
Molecular Weight: 592.1
Purity: 99.5% chemically pure (achiral HPLC), 100% optically pure (chiral HPLC)
QC: MS, 1HNMR, HPLC, Chiral HPLC, and Quantitative Elemental Analysis
Solubility: soluble in DMSO (59.6 mg/ml, 100mM)
Storage: Store at 0°C (short term), -20°C (long term), desiccated
Background Information:
GSK923295 (GSK923295) is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity with a Ki value of 3.2nM (Ref. 1). Display a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors. It is currently in clinical evaluations.
