eIF2α Rabbit mAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

eIF2α Rabbit mAb

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EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha

SKU: A21221 分类: ,

产品参数

货号 A21221
产品名称eIF2α Rabbit mAb
供货商名称 Syd Labs, Inc.
品牌名 Syd Labs
别称 EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha
基因名称 EIF2S1
蛋白名 EIF2S1
Uniprot/Swissprot ID P05198
Entrez GeneID 1965
克隆号 ARC52379
克隆性 Monoclonal
来源 Rabbit
反应性 Human, Mouse, Rat
偶联 Unconjugated
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文献

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).