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PA007162.m1DA: Syd Labs 体内实验级重组抗小鼠PD-1单克隆抗体（克隆号RMP1-14.1），小鼠IgG1-D265A Kappa（In Vivo Grade Recombinant Anti-mouse PD-1 Monoclonal Antibody (Clone RMP1-14.1), Mouse IgG1-D265A Kappa）

PD-1功能抗体（RMP1-14）部分参考文献:

Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.
van der Werf, N., et al. PLoS Pathog. 2013 Mar;9(3):e1003215. doi: 10.1371/journal.ppat.1003215. PMID: 23516361
We further demonstrate that we can therapeutically manipulate the intrinsic functional quality of hypo-responsive Th2 cells via the PD-1/PD-L2 co-inhibitory pathway to reawaken them and enhance resistance to infection. …The onset of hypo-responsiveness was accompanied by increased expression of PD-1 by IL-4gfp+ Th2 cells, and in vivo PD-1 blockade led to increased resistance to infection and a long-term increase in Th2 cell functional quality. …To investigate whether L. sigmodontis-induced Th2 cell hypo-responsiveness was associated with PD-1 co-inhibition, the expression of PD-1 by IL-4gfp+ Th2 cells was assessed. …To test the hypothesis that blocking PD-1 signalling on the hypo-responsive Th2 cells in vitro could re-activate their functional responsiveness, IL-4gfp+ Th2 cells were purified from the PC 60 d post-L. …There was a significant reduction in the number of healthy uterine eggs within female parasites from PD-1 treated mice at d 60 pi.
Tags: anti-mouse PD-1 RMP1-14 antibody in mouse tumor model; function of anti-mouse PD-1 RMP1-14

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.
Holmgaard, R. B., et al. J Exp Med. 2013 Jul 1;210(7):1389-402. doi: 10.1084/jem.20130066. PMID: 23752227
This was also observed with antibodies targeting PD-1/PD-L1 and GITR. …Along these lines, we demonstrate that inhibition/absence of IDO in combination with therapies targeting immune checkpoints such as CTLA-4, PD-1/PD-L1, and GITR synergize to control tumor outgrowth and enhance overall survival in different tumor models. …In contrast to effector T cells, there was no significant increase in proliferation or up-regulation of PD-1 or ICOS by the tumor-infiltrating T reg cells with anti-CTLA-4 therapy. …Anti-PD-1/PD-L1 treatment delayed tumor progression in B16F10-bearing WT mice, but resulted in only modest improvement in survival. …However, anti-PD-1/PD-L1 treatment in IDO?/? mice resulted in significantly reduced tumor growth and improved survival.
Tags: bioactivity of anti-mouse PD-1 RMP1-14; anti-mouse PD-1 RMP1-14 of low endotoxin

Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells.
John, L. B., et al. Clin Cancer Res. 2013 Oct 15;19(20):5636-46. doi: 10.1158/1078-0432.CCR-13-0458. PMID: 23873688
In this study, we show that blockade of the PD-1 immunosuppressive pathway using an anti-PD-1 antibody can significantly enhance the antitumor efficacy of genetically modified T cells expressing a chimeric antigen receptor (CAR). …The PD-1 pathway has emerged as another promising target for cancer therapy. …Engagement of the PD-1/PD-L1 pathway results in the phosphorylation of tyrosine-based motifs in the cytoplasmic tail of the PD-1 inhibitory receptor, which promotes the recruitment of SHP2 phosphatase leading to dephosphorylation of PI3K. …Recent trials using a fully human IgG4 PD-1 monocloncal antibody (mAb; BMS-936558) have reported durable clinical responses in patients with advanced melanoma, non?small cell lung, renal cell, as well as hematologic malignancies. …Hence, in this study, we hypothesized that CAR T-cell therapy in combination with PD-1 blockade may overcome PD-L1+ tumor immunosuppression, thereby leading to improved therapeutic efficacy.
Tags: anti-mouse PD-1 RMP1-14 mAb of low endotoxin; clone RMP1-14 of anti-mouse PD-1 antibody

了解更多抗小鼠PD-1单克隆抗体（clone：RMP1-14）参考文献，请查看：抗小鼠PD-1单抗（克隆号RMP1-14）参考文献

Syd Labs抗小鼠PD-1重组抗体（克隆号RMP1-14.1），小鼠IgG1-D265A Kappa（货号：PA007162.m1DA）推荐同型对照抗体:

重组小鼠IgG1-D265A同型对照抗体，体内实验级（In Vivo Grade Recombinant Mouse IgG1-D265A Isotype Control Antibody）

Syd Labs提供以下抗小鼠PD 1抗体（anti-mouse PD 1 antibodies）:

体内实验级重组抗小鼠PD1单克隆抗体（克隆号29F.1A12.1）（In vivo grade recombinant anti-mouse PD1 monoclonal antibodies （Clone 29F.1A12.1））
体内实验级重组抗小鼠PD-1单克隆抗体（克隆号RMP1-14.1）（In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies （Clone RMP1-14.1））
体内实验级重组鼠化抗小鼠PD 1单克隆抗体（In Vivo Grade Recombinant Murinized Anti-mouse PD-1 Mouse Monoclonal Antibody (Clone RMP1-14.1) 

Syd Labs还提供以下体内实验级重组抗小鼠PD-1单克隆抗体(克隆号RMP1-14.1)突变体:

体内实验级重组抗小鼠PD-1单克隆抗体(克隆号RMP1-14.1)，小鼠IgG2c-LALAPG Kappa
体内实验级重组抗小鼠PD-1单克隆抗体(克隆号RMP1-14.1)，小鼠IgG2a-LALAPG Kappa

关于PA007162.m1DA Syd Labs抗小鼠PD 1抗体您可能还会搜索:

PA007162.r2a Syd Labs
PA007162.m2cLA Syd Labs
PA007162.m2aLA Syd Labs
PA007162.m1DA Syd Labs抗小鼠PD1抗体
PA007162.m2a RMP1-14
PA007162.rt Syd Labs 抗小鼠PD 1抗体
PA007162.m2c Syd Labs 抗小鼠PD-1抗体
PA007162.m1 RMP1-14
CP002 bioxcell

背景知识

The rat anti-mouse PD-1 monoclonal antibody （大鼠抗小鼠PD-1单克隆抗体）（clone No. RMP1-14, rat IgG2a kappa）reacts with the mouse PD-1 protein (抗小鼠CD279抗体 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein.

Our recombinant RMP1-14 antibodies （重组抗小鼠CD279单克隆抗体）have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody（大鼠抗小鼠PD-1抗体） （hybridoma clone name or number: RMP1-14）. The murinized anti-mouse PD-1 recombinant antibody has not only the constant regions of the mouse IgG antibodies but also the murinized variable regions.

抗小鼠PD-1抗体(RMP1-14 PA007162.m1DA)相关问答:

Question: Which anti-mouse PD1 antibody works the best?
Answer: (by AI) There are several anti-mouse PD1 antibodies available in the market: Clones RMP1-14, 29F.1A12, and J43. All three of these antibodies are commonly used to block PD-1 signaling in vivo in murine tumor models and other mouse models. These three clones all have extensive multi-year publication records supporting them. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production costimulated by macrophages (but not by dendritic cells and B cells). (by Syd Labs) Syd Labs offers anti-mouse PD-1 monoclonal antibodies（抗小鼠PD-1单克隆抗体） based on the sequences of clones RMP1-14 and 29F.1A12. Syd Labs provides in vivo grade recombinant antibodies including engineered antibodies for the clones RMP1-14 and 29F.1A12. Even though mouse and rat are close, rat antibodies may still induce immunogenecity in mice. Antibodies with murinized variable regions and mouse constant regions behave like humanized antibody drugs in animal models using mice. In addition, the mouse IgG2c antibody is produced in certain inbred strains such as C57BL/6, C57BL/10, SJL, and NOD, which does not express the mouse IgG2a antibody（小鼠IgG2a抗体）; the mouse IgG2a antibody（小鼠IgG2a抗体） is produced in other inbred strains such as BALB/c and Swiss Webster mice, which does not express the mouse IgG2c antibody（小鼠IgG2c抗体）. If one uses the C57BL/6 mouse strain for animal model research, it is better to use the IgG2c antibodies rather than the IgG2a antibodies. The format with the Fc silenced, Fc silent, or Fcs with silenced effector function, such as LALAPG mutation, is the most popular for anti-mouse PD1 antibodies（抗小鼠PD1抗体）（clones RMP1-14 and 29F.1A12） and anti-mouse PD-L1 antibodies（抗小鼠PD-L1抗体）（clone 10F.9G2）.

Question: Do you produce any recombinant Fc-silenced RMP1-14 antibody（重组Fc-silenced RMP1-14抗体）?
Answer: Sure, we provide various recombinant Fc silent RMP1-14 antibodies（重组Fc silent RMP1-14抗体）, such as mIgG2c LALAPG, mIgG2a LALAPG, and mIgG1 D265A. We also provide custom recombinant antibody production service to produce other engineered versions of recombinant RMP1-14 antibodies（重组RMP1-14抗体）. We have a promotion program running: We provide 1 mg PA007162.m2cLA （In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c-LALAPG Kappa Monoclonal Antibody（体内实验级重组抗小鼠PD-1小鼠IgG2c-LALAPG Kappa单克隆抗体）（Clone RMP1-14.1）） for free in exchange of results. Please contact us to know more about the free RMP1-14 antibody.

Question: What is the difference among PA007162.r2a, PA007162.m2cLA, and PA007162.mm2cLA?
Answer: PA007162.r2a is the recombinant anti-mouse PD-1 monoclonal antibody（重组抗小鼠PD-1单克隆抗体） （rat IgG2a kappa, clone RMP1-14.1） produced in CHO cells or HEK293 cells if needed. It has the same variable region and constant region sequences as the rat anti-mouse PD-1 monoclonal antibody（大鼠抗小鼠PD-1单克隆抗体） from the hybridoma clone of RMP1-14. Rat antibodies may cause high immuogenicity in mice; thus, at least recombinant antibodies with mouse antibody constant regions should be used to replace the rat antibody constant regions. PA007162.m2cLA is the recombinant anti-mouse PD-1 antibody（RPM1-14单抗抗小鼠PD 1） whose constant regions are mouse IgG2c LALAPG kappa. We further murinize the antibody variable region sequences of PA007162.m2cLA to produce PA007162.mm2cLA.

请记住我们的产品信息: Syd Labs（货号：PA007162.m1DA）体内实验级重组抗小鼠PD-1单克隆抗体(克隆号RMP1-14.1)，小鼠IgG1-D265A Kappa: PA007162.m1DA Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Monoclonal Antibody (Clone RMP1-14.1), Mouse IgG1-D265A Kappa