XRCC5 Polyclonal Antibody

XRCC5 Polyclonal Antibody

In stock

Conditions of optimal XRCC5 polyclonal antibody performance should be determined experimentally by the investigator.

SKU: PA003728-PA1641 分类: ,
货号 PA003728-PA1641
产品名称XRCC5 Polyclonal Antibody
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase II, 80 kDa subunit, CTC box binding factor 85 kDa subunit, CTC85
同种型 Rabbit IgG.
反应性 Human;
免疫源 A synthetic peptide corresponding to a sequence at the C-terminal of human XRCC5.
纯化 Immunogen affinity purified.
抗体形式 Lyophilized.
稳定性与存储 Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
注意事项 Conditions of optimal XRCC5 antibody performance should be determined experimentally by the investigator.
线下下单 Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

描述

PA003728-PA1641: XRCC5 Polyclonal Antibody
Introduction
XRCC5(X-ray Repair,Complementing Defective ,In Chinese Hamster, 5), also known as Ku80 or Ku86, is a protein that in humans, is encoded by the XRCC5 gene. The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining (NHEJ) pathway. The XRCC5 gene is mapped to 2q35. Human colon cancer cells heterozygous for Ku86 are haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku86 allele results in cells with a drastically reduced doubling time. The Ku86 locus is essential in human somatic tissue culture cells by experiments demonstration. A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity.
Other XRCC5 Antibodies:
XRCC5 Polyclonal Antibody
XRCC5 Polyclonal Antibody
XRCC5 Polyclonal Antibody

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