Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg
Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg. The research grade rituximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Rituximab biosimilar CHO stable cell line is available for licensing to manufacture the rituximab biosimilar protein.
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| 货号 | C010P.LA.05 |
|---|---|
| 产品名称 | Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | 悉得（Syd Labs） |
| 别称 | Anti-CD20 Chimeric Monoclonal Antibody |
| 概述 | Recombinant Humanized IgG1 Monoclonal Antibody. |
| 同种型 | Human IgG1 kappa. |
| 来源 | The monoclonal antibody rituximab biosimilar was produced in the Rituximab biosimilar CHO stable cell line. |
| 特异性 | The monoclonal antibody rituximab biosimilar specifically binds to the human TNF alpha. |
| 应用 | ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by rituximab. |
| 抗体形式 | 0.2 uM filtered solution, pH 6.5, no stabilizers or preservatives. |
| 内毒素 | < 0.05 EU per 1 mg of the protein by the LAL method. |
| 纯度 | >95% by SDS-PAGE under reducing conditions and HPLC. |
| 运输 | The Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 稳定性与存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |
| 注意事项 | The research grade rituximab biosimilar protein is for research use only (RUO). Recombinant human IgG1 isotype controls are available. Rituximab biosimilar CHO stable cell line is available for licensing to manufacture the rituximab biosimilar protein. |
| 线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com或联系我们 |
描述
C010P.LA.05: Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg
Recombinant Humanized IgG1 Monoclonal Antibody.
Background
B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.
Rituximab, a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
Syd Labs also provides the following research grade antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade (VEGF-A)
Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli)
Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR)
Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu)
Infliximab biosimilar, research grade (TNF alpha)
Adalimumab biosimilar, research grade (TNF alpha)
Rituximab biosimilar, research grade (CD20)
Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF)
Palivizumab Biosimilar, research grade (RSV)
Omalizumab biosimilar, research grade (IgE)
Eculizumab biosimilar, research grade (C5)
Please remember our product information: Rituximab Biosimilar, L234A L235A P329G (LALAPG) Fc Silent Mutant, Endotoxin 0.05 EU/mg: C010P.LA.05 Syd Labs
