Recombinant Human FVIIa Protein
Syd Labs Recombinant Human FVIIa Protein BP000036-GD11, The potency per mg of recombinant human FVIIa protein was tested and found to be 50,000 Units/mg.
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| 货号 | BP000036-GD11 |
|---|---|
| 产品名称 | Recombinant Human FVIIa Protein |
| 供货商名称 | Syd Labs, Inc. |
| 品牌名 | 悉得（Syd Labs） |
| 别称 | Coagulation Factor VII |
| 来源 | 293 cell derived. |
| 形式 | a 0.2 mm filtered solution (0.2 mg/ml) of sodium chloride (2.3 ug/ml), calcium chloride dihydrate (1.5 ug/ml), glycylglycine (1.3 ug/ml), polysorbate 80 (0.1 ug/ml), mannitol (25 ug/ml), sucrose (10 ug/ml), methionine (0.5 ug/ml), and histidine (1.6 ug/ml). pH. 6.0 |
| 纯度 | > 95%, by SDS-PAGE under reducing conditions. |
| 内毒素 | <1.0 EU per 1 ug of the protein by the LAL method. |
| 运输 | The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below. |
| 注意事项 | Conditions of optimal FVII and FVIIa Proteins performance should be determined experimentally by the investigator. |
| 线下下单 | 电话: 18162660842微信: duozhaozhao_2017Email: message@sydlabs.comOr 联系我们 |
描述
BP000036-GD11: Recombinant Human FVIIa Protein
Background
Coagulation factor VII (FVII) which is a vitamin K-dependent factor essential for hemostasis. FVII circulates in the blood in a zymogen form, and is converted to an active form (FVIIa) by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor (FVIIa) then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa.
References:
1. Kenet G, et al., 1999, Lancet 354 (9193): 1879.
2. Roberts H, et al., 2004, Blood. 104 (13): 3858-64.
3. Mayer S, et al., 2005, N. Engl. J. Med. 352 (8): 777-85.
4. O’Connell K, et al., 2006, JAMA. 295 (3): 293-8.
BP000036-GD11: Recombinant Human FVIIa Protein
Source: 293 cell derived.
Ala61-Pro466, Accession# NP_000122.1
N-terminal sequence analysis: Ala
Predicted molecular mass: 47 kDa
SDS-PAGE: 42 kDa, reducing conditions
The potency per mg of recombinant human FVIIa protein was tested and found to be 50,000 Units/mg.
Endotoxin Level: <1.0 EU per 1 ug of the protein by the LAL method.
Purity > 95%, by SDS-PAGE under reducing conditions.
Formulation: a 0.2 mm filtered solution (0.2 mg/ml) of sodium chloride (2.3 ug/ml), calcium chloride dihydrate (1.5 ug/ml), glycylglycine (1.3 ug/ml), polysorbate 80 (0.1 ug/ml), mannitol (25 ug/ml), sucrose (10 ug/ml), methionine (0.5 ug/ml), and histidine (1.6 ug/ml). pH. 6.0
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month if stored at 2°C to 8°C under sterile conditions.
Please remember our product information: Recombinant Human FVIIa Protein: BP000036-GD11 Syd Labs
