PRDX3 Polyclonal Antibody

PRDX3 Polyclonal Antibody

In stock

Conditions of optimal PRDX3 polyclonal antibody performance should be determined experimentally by the investigator.

SKU: PA006683-PA1836 分类: ,
货号 PA006683-PA1836
产品名称PRDX3 Polyclonal Antibody
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 peroxiredoxin 3, AOP-1, MER5, SP-22, PRX3
同种型 Rabbit IgG.
反应性 Human, Rat, Mouse.
免疫源 A synthetic peptide corresponding to a sequence at the C-terminal of mouse PRDX3, identical to the related rat sequence and different from the related human sequence by three sequences.
纯化 Immunogen affinity purified.
抗体形式 Lyophilized.
稳定性与存储 Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
注意事项 Conditions of optimal PRDX3 Antibody performance should be determined experimentally by the investigator.
线下下单 Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com

描述

PA006683-PA1836: PRDX3 Polyclonal Antibody
Introduction
PRDX3(peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3,is localized exclusively in mitochondria. The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.
Other PRDX3 Antibody:
PRDX3 Polyclonal Antibody

PRDX3 Proteins:
Recombinant Human PRDX3 Protein
Recombinant Human PRDX3 Protein

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