PRDX3 Polyclonal Antibody
Conditions of optimal PRDX3 polyclonal antibody performance should be determined experimentally by the investigator.
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货号 | PA006683-PA1836 |
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产品名称 | PRDX3 Polyclonal Antibody |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | peroxiredoxin 3, AOP-1, MER5, SP-22, PRX3 |
同种型 | Rabbit IgG. |
反应性 | Human, Rat, Mouse. |
免疫源 | A synthetic peptide corresponding to a sequence at the C-terminal of mouse PRDX3, identical to the related rat sequence and different from the related human sequence by three sequences. |
纯化 | Immunogen affinity purified. |
抗体形式 | Lyophilized. |
稳定性与存储 | Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |
注意事项 | Conditions of optimal PRDX3 Antibody performance should be determined experimentally by the investigator. |
线下下单 | Syd Labs, Inc. 4 Avenue E, Hopkinton, MA 01748 USA. Phone: 1-617-401-8149 Fax: 1-617-606-5019 Email: message@sydlabs.com |
描述
PA006683-PA1836: PRDX3 Polyclonal Antibody
Introduction
PRDX3(peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3,is localized exclusively in mitochondria. The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.
Other PRDX3 Antibody:
PRDX3 Polyclonal Antibody
PRDX3 Proteins:
Recombinant Human PRDX3 Protein
Recombinant Human PRDX3 Protein