Phospho-PKC zeta-T560 Rabbit mAb

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Phospho-PKC zeta-T560 Rabbit mAb

In stock

PKC2; PKC-ZETA

SKU: AP1149 分类: ,
货号 AP1149
产品名称Phospho-PKC zeta-T560 Rabbit mAb
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 PKC2; PKC-ZETA
基因名称 PRKCZ
蛋白名 PRKCZ
Uniprot/Swissprot ID Q05513
Entrez GeneID 5590
克隆号 ARC1617
克隆性 Monoclonal
来源 Rabbit
反应性 Human, Rat
偶联 Unconjugated
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描述

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

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