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货号 | AP1244 |
---|---|
产品名称 | Phospho-MLKL-S358 Rabbit pAb |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
别称 | hMLKL |
基因名称 | MLKL |
蛋白名 | MLKL |
Uniprot/Swissprot ID | Q8NB16 |
Entrez GeneID | 197259 |
克隆性 | Polyclonal |
来源 | Rabbit |
反应性 | Human, Rat |
偶联 | Unconjugated |
注意事项 | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com |
描述
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
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