Phospho-MLKL-S358 Rabbit pAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

Phospho-MLKL-S358 Rabbit pAb

In stock

hMLKL

SKU: AP1244 分类: ,
货号 AP1244
产品名称Phospho-MLKL-S358 Rabbit pAb
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 hMLKL
基因名称 MLKL
蛋白名 MLKL
Uniprot/Swissprot ID Q8NB16
Entrez GeneID 197259
克隆性 Polyclonal
来源 Rabbit
反应性 Human, Rat
偶联 Unconjugated
注意事项 Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
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描述

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

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