Phospho-MAP2K3-S189 + MAP2K6-S207 Rabbit pAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

Phospho-MAP2K3-S189 + MAP2K6-S207 Rabbit pAb

In stock

SKU: AP1112 分类: ,
货号 AP1112
产品名称Phospho-MAP2K3-S189 + MAP2K6-S207 Rabbit pAb
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
基因名称 MAP2K3/MAP2K6
蛋白名 MAP2K3/MAP2K6
Uniprot/Swissprot ID P46734/P52564
克隆性 Polyclonal
来源 Rabbit
反应性 Human, Mouse
注意事项 Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
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描述

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

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