Phospho-MAP2K3-S189 + MAP2K6-S207 Rabbit pAb
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货号 | AP1112 |
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产品名称 | Phospho-MAP2K3-S189 + MAP2K6-S207 Rabbit pAb |
供货商名称 | Syd Labs, Inc. |
品牌名 | 悉得(Syd Labs) |
基因名称 | MAP2K3/MAP2K6 |
蛋白名 | MAP2K3/MAP2K6 |
Uniprot/Swissprot ID | P46734/P52564 |
克隆性 | Polyclonal |
来源 | Rabbit |
反应性 | Human, Mouse |
注意事项 | Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com. |
线下下单 | 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com |
描述
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]