Phospho-c-Abl-Y412 Rabbit pAb

Phospho-Myosin Light Chain 2-S19 Rabbit mAbPhospho-Myosin Light Chain 2-S19 Rabbit mAb

Phospho-c-Abl-Y412 Rabbit pAb

In stock

ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl

SKU: AP1060 分类: ,
货号 AP1060
产品名称Phospho-c-Abl-Y412 Rabbit pAb
供货商名称 Syd Labs, Inc.
品牌名 悉得(Syd Labs)
别称 ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
基因名称 ABL1
蛋白名 ABL1
Uniprot/Swissprot ID P00519
Entrez GeneID 25
克隆性 Polyclonal
来源 Rabbit
反应性 Human, Mouse, Rat
注意事项 Products will be shipped from the warehouse in Massachusetts. Promotion is running from time to time. Welcome to send a request for quote to message@sydlabs.com.
线下下单 武汉多找找科技有限公司 电话: 18162581039 微信: duozhaozhao2024 Email: message@sydlabs.com

描述

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

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